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1FTN

CRYSTAL STRUCTURE OF THE HUMAN RHOA/GDP COMPLEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000902biological_processcell morphogenesis
A0001764biological_processneuron migration
A0001822biological_processkidney development
A0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
A0002363biological_processalpha-beta T cell lineage commitment
A0003100biological_processregulation of systemic arterial blood pressure by endothelin
A0003189biological_processaortic valve formation
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006357biological_processregulation of transcription by RNA polymerase II
A0007010biological_processcytoskeleton organization
A0007049biological_processcell cycle
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007264biological_processsmall GTPase-mediated signal transduction
A0007266biological_processRho protein signal transduction
A0007519biological_processskeletal muscle tissue development
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010812biological_processnegative regulation of cell-substrate adhesion
A0010975biological_processregulation of neuron projection development
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0016787molecular_functionhydrolase activity
A0017022molecular_functionmyosin binding
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0021795biological_processcerebral cortex cell migration
A0021861biological_processforebrain radial glial cell differentiation
A0030027cellular_componentlamellipodium
A0030036biological_processactin cytoskeleton organization
A0030054cellular_componentcell junction
A0030154biological_processcell differentiation
A0030334biological_processregulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0030521biological_processandrogen receptor signaling pathway
A0030667cellular_componentsecretory granule membrane
A0031122biological_processcytoplasmic microtubule organization
A0031982cellular_componentvesicle
A0032154cellular_componentcleavage furrow
A0032467biological_processpositive regulation of cytokinesis
A0032587cellular_componentruffle membrane
A0032956biological_processregulation of actin cytoskeleton organization
A0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
A0033688biological_processregulation of osteoblast proliferation
A0034329biological_processcell junction assembly
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0035385biological_processRoundabout signaling pathway
A0036089biological_processcleavage furrow formation
A0038027biological_processapolipoprotein A-I-mediated signaling pathway
A0042476biological_processodontogenesis
A0042995cellular_componentcell projection
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043149biological_processstress fiber assembly
A0043197cellular_componentdendritic spine
A0043296cellular_componentapical junction complex
A0043297biological_processapical junction assembly
A0043366biological_processbeta selection
A0043542biological_processendothelial cell migration
A0043931biological_processossification involved in bone maturation
A0044319biological_processwound healing, spreading of cells
A0045198biological_processestablishment of epithelial cell apical/basal polarity
A0045666biological_processpositive regulation of neuron differentiation
A0045792biological_processnegative regulation of cell size
A0046638biological_processpositive regulation of alpha-beta T cell differentiation
A0050919biological_processnegative chemotaxis
A0051301biological_processcell division
A0051496biological_processpositive regulation of stress fiber assembly
A0051893biological_processregulation of focal adhesion assembly
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060193biological_processpositive regulation of lipase activity
A0061430biological_processbone trabecula morphogenesis
A0070062cellular_componentextracellular exosome
A0070507biological_processregulation of microtubule cytoskeleton organization
A0071222biological_processcellular response to lipopolysaccharide
A0071345biological_processcellular response to cytokine stimulus
A0071526biological_processsemaphorin-plexin signaling pathway
A0071803biological_processpositive regulation of podosome assembly
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0071944cellular_componentcell periphery
A0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
A0090307biological_processmitotic spindle assembly
A0090324biological_processnegative regulation of oxidative phosphorylation
A0097049biological_processmotor neuron apoptotic process
A0097498biological_processendothelial tube lumen extension
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099159biological_processregulation of modification of postsynaptic structure
A0101003cellular_componentficolin-1-rich granule membrane
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A1902766biological_processskeletal muscle satellite cell migration
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1903673biological_processmitotic cleavage furrow formation
A1904695biological_processpositive regulation of vascular associated smooth muscle contraction
A1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
A1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
A1990869biological_processcellular response to chemokine
A2000177biological_processregulation of neural precursor cell proliferation
A2000406biological_processpositive regulation of T cell migration
A2000672biological_processnegative regulation of motor neuron apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 300
ChainResidue
ATHR19
ATHR37
AGDP200
AHOH304
AHOH310
AHOH317

site_idAC2
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GDP A 200
ChainResidue
AGLY17
ALYS18
ATHR19
ACYS20
APHE30
ALYS118
AASP120
ALEU121
ASER160
AALA161
ALYS162
AMG300
AHOH301
AHOH304
AHOH310
AHOH317
AHOH319
AHOH332
AHOH340
AHOH352
AHOH375
AHOH412
AGLY14
AALA15
ACYS16

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:10748207, ECO:0000269|PubMed:12777804
ChainResidueDetails
AGLY12
AASN117

site_idSWS_FT_FI2
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P62820
ChainResidueDetails
APHE30
AASP59
ASER160

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: (Microbial infection) Cleavage; by yopT => ECO:0000269|PubMed:12062101, ECO:0000269|PubMed:12538863
ChainResidueDetails
AGLY189

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
ATYR34

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
ATHR37

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: (Microbial infection) ADP-ribosylasparagine; by botulinum toxin => ECO:0000305|PubMed:1328215
ChainResidueDetails
AASN41

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: 5-glutamyl serotonin => ECO:0000250|UniProtKB:Q9QUI0
ChainResidueDetails
AGLN63

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKG/PRKG1 => ECO:0000269|PubMed:11162591
ChainResidueDetails
ASER188

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P61585
ChainResidueDetails
ACYS190

site_idSWS_FT_FI10
Number of Residues3
DetailsLIPID: (Microbial infection) N6-stearoyl lysine => ECO:0000269|PubMed:30061757
ChainResidueDetails
ALYS185
ALYS186
ALYS187

site_idSWS_FT_FI11
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P61585
ChainResidueDetails
ACYS190

site_idSWS_FT_FI12
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR34

site_idSWS_FT_FI13
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ATHR37

site_idSWS_FT_FI14
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831
ChainResidueDetails
ALYS135

218853

PDB entries from 2024-04-24

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