Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 560 |
| Chain | Residue |
| A | LYS74 |
| A | ARG97 |
| A | GLY303 |
| A | PHE304 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 560 |
| Chain | Residue |
| B | LYS74 |
| B | ARG97 |
| B | GLY303 |
| B | PHE304 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 561 |
| Chain | Residue |
| A | MET533 |
| A | ARG178 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 562 |
| Chain | Residue |
| A | SER44 |
| A | ASP46 |
| A | LYS256 |
| A | HOH690 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 563 |
| Chain | Residue |
| A | ARG175 |
| A | ARG178 |
| A | GLY537 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 564 |
| Chain | Residue |
| A | ARG319 |
| A | ASN442 |
| A | LEU443 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 565 |
| Chain | Residue |
| A | ASN382 |
| A | ALA383 |
| A | TRP412 |
| A | HOH597 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 566 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 561 |
| Chain | Residue |
| A | ALA188 |
| B | ARG175 |
| B | ARG178 |
| B | MET533 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 562 |
| Chain | Residue |
| B | SER44 |
| B | ASP46 |
| B | LYS256 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 563 |
| Chain | Residue |
| B | ARG162 |
| B | THR163 |
| B | ILE164 |
| B | HOH617 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CS A 567 |
| Chain | Residue |
| A | GLU98 |
| A | PRO99 |
| A | ILE125 |
| A | LEU127 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CS B 564 |
| Chain | Residue |
| B | GLU98 |
| B | PRO99 |
| B | ILE125 |
| B | ASN126 |
| B | LEU127 |
Functional Information from PROSITE/UniProt
| site_id | PS00721 |
| Number of Residues | 11 |
| Details | FTHFS_1 Formate--tetrahydrofolate ligase signature 1. GIKGGAAGGGY |
| Chain | Residue | Details |
| A | GLY106-TYR116 | |
| site_id | PS00722 |
| Number of Residues | 12 |
| Details | FTHFS_2 Formate--tetrahydrofolate ligase signature 2. VATVRALKmHGG |
| Chain | Residue | Details |
| A | VAL331-GLY342 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01543","evidenceCode":"ECO:0000255"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1eg7 |
| Chain | Residue | Details |
| A | LYS74 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1eg7 |
| Chain | Residue | Details |
| B | LYS74 | |
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 385 |
| Chain | Residue | Details |
| A | LYS74 | electrostatic stabiliser |
| A | THR76 | steric role |
| A | ARG97 | electrostatic stabiliser |
| A | LYS108 | electrostatic stabiliser |
| A | ALA276 | electrostatic stabiliser |
| A | PHE304 | electrostatic stabiliser |
| A | PHE384 | activator |
| A | TRP412 | activator |
| site_id | MCSA2 |
| Number of Residues | 8 |
| Details | M-CSA 385 |
| Chain | Residue | Details |
| B | LYS74 | electrostatic stabiliser |
| B | THR76 | steric role |
| B | ARG97 | electrostatic stabiliser |
| B | LYS108 | electrostatic stabiliser |
| B | ALA276 | electrostatic stabiliser |
| B | PHE304 | electrostatic stabiliser |
| B | PHE384 | activator |
| B | TRP412 | activator |
