Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 166 |
| Chain | Residue |
| A | HIS119 |
| A | HIS123 |
| A | HIS129 |
| A | WAY169 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 167 |
| Chain | Residue |
| A | HIS69 |
| A | ASP71 |
| A | HIS84 |
| A | HIS97 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CA A 168 |
| Chain | Residue |
| A | GLY77 |
| A | PRO78 |
| A | SER79 |
| A | GLY80 |
| A | LEU81 |
| A | ASP99 |
| A | GLU102 |
| A | ASP76 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE WAY A 169 |
| Chain | Residue |
| A | GLY80 |
| A | LEU81 |
| A | LEU82 |
| A | LEU115 |
| A | HIS119 |
| A | HIS123 |
| A | HIS129 |
| A | PRO139 |
| A | ZN166 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHSL |
| Chain | Residue | Details |
| A | VAL116-LEU125 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | GLU120 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305 |
| Chain | Residue | Details |
| A | ASP25 | |
| A | ASP99 | |
| A | ASP100 | |
| A | GLU102 | |
| A | ASP59 | |
| A | ASP76 | |
| A | GLY77 | |
| A | SER79 | |
| A | LEU81 | |
| A | ASN91 | |
| A | GLY93 | |
| A | ASP95 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860 |
| Chain | Residue | Details |
| A | HIS69 | |
| A | ASP71 | |
| A | HIS84 | |
| A | HIS97 | |
| A | HIS119 | |
| A | HIS123 | |
| A | HIS129 | |
| A | MET137 | |
| Chain | Residue | Details |
| A | ASN14 | |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN49 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU120 | |
| A | MET137 | |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU120 | |
