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1FI8

RAT GRANZYME B [N66Q] COMPLEXED TO ECOTIN [81-84 IEPD]

Functional Information from GO Data
ChainGOidnamespacecontents
A0001913biological_processT cell mediated cytotoxicity
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005769cellular_componentearly endosome
A0006508biological_processproteolysis
A0006915biological_processapoptotic process
A0008236molecular_functionserine-type peptidase activity
A0017148biological_processnegative regulation of translation
A0031640biological_processkilling of cells of another organism
A0042267biological_processnatural killer cell mediated cytotoxicity
A0042742biological_processdefense response to bacterium
A0043231cellular_componentintracellular membrane-bounded organelle
A0044194cellular_componentcytolytic granule
A0051402biological_processneuron apoptotic process
A0051603biological_processproteolysis involved in protein catabolic process
A0051604biological_processprotein maturation
A0060545biological_processpositive regulation of necroptotic process
A0070269biological_processpyroptosis
A0140507biological_processgranzyme-mediated programmed cell death signaling pathway
B0001913biological_processT cell mediated cytotoxicity
B0004252molecular_functionserine-type endopeptidase activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005769cellular_componentearly endosome
B0006508biological_processproteolysis
B0006915biological_processapoptotic process
B0008236molecular_functionserine-type peptidase activity
B0017148biological_processnegative regulation of translation
B0031640biological_processkilling of cells of another organism
B0042267biological_processnatural killer cell mediated cytotoxicity
B0042742biological_processdefense response to bacterium
B0043231cellular_componentintracellular membrane-bounded organelle
B0044194cellular_componentcytolytic granule
B0051402biological_processneuron apoptotic process
B0051603biological_processproteolysis involved in protein catabolic process
B0051604biological_processprotein maturation
B0060545biological_processpositive regulation of necroptotic process
B0070269biological_processpyroptosis
B0140507biological_processgranzyme-mediated programmed cell death signaling pathway
C0004867molecular_functionserine-type endopeptidase inhibitor activity
D0004867molecular_functionserine-type endopeptidase inhibitor activity
E0004867molecular_functionserine-type endopeptidase inhibitor activity
F0004867molecular_functionserine-type endopeptidase inhibitor activity
Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
ALEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. ASfrGDSGGPLV
ChainResidueDetails
AALA189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Reactive bond
ChainResidueDetails
CASP84
EASP84
ASER195
BHIS57
BASP102
BSER195

site_idSWS_FT_FI2
Number of Residues2
DetailsSITE: Mediates preference for Asp-containing substrates => ECO:0000269|PubMed:10966646
ChainResidueDetails
AARG226
BARG226

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PDB entries from 2024-06-12

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