1FH2
TRANSTHYRETIN STABILITY AS A KEY FACTOR IN AMYLOIDOGENESIS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006144 | biological_process | purine nucleobase metabolic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070324 | molecular_function | thyroid hormone binding |
| B | 0005179 | molecular_function | hormone activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006144 | biological_process | purine nucleobase metabolic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070324 | molecular_function | thyroid hormone binding |
Functional Information from PROSITE/UniProt
| site_id | PS00769 |
| Number of Residues | 13 |
| Details | TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS |
| Chain | Residue | Details |
| A | TYR105-SER117 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11418763, ECO:0007744|PDB:1ICT |
| Chain | Residue | Details |
| A | LYS15 | |
| A | GLU54 | |
| A | SER117 | |
| B | LYS15 | |
| B | GLU54 | |
| B | SER117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Sulfocysteine => ECO:0000269|PubMed:17175208, ECO:0007744|PDB:2H4E |
| Chain | Residue | Details |
| A | CYS10 | |
| B | CYS10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269|PubMed:18221012 |
| Chain | Residue | Details |
| A | GLU42 | |
| B | GLU42 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02767 |
| Chain | Residue | Details |
| A | SER52 | |
| B | SER52 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19167329 |
| Chain | Residue | Details |
| A | ASN98 | |
| B | ASN98 |
