Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000049 | molecular_function | tRNA binding |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002161 | molecular_function | aminoacyl-tRNA editing activity |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004822 | molecular_function | isoleucine-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006412 | biological_process | translation |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006428 | biological_process | isoleucyl-tRNA aminoacylation |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0106074 | biological_process | aminoacyl-tRNA metabolism involved in translational fidelity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K T 301 |
| Chain | Residue |
| T | C32 |
| T | U33 |
| T | U36 |
| T | A38 |
| T | HOH1267 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | CYS886 |
| A | CYS889 |
| A | CYS906 |
| A | CYS909 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1992 |
| Chain | Residue |
| A | ASP13 |
| A | HIS201 |
| A | HIS770 |
| A | HOH2070 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG T 1201 |
| Chain | Residue |
| T | HOH1292 |
| T | HOH1293 |
| T | HOH1294 |
| T | HOH1295 |
| T | HOH1296 |
| T | HOH1297 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG T 1202 |
| Chain | Residue |
| T | HOH1298 |
| T | HOH1299 |
| T | HOH1300 |
| T | HOH1301 |
| T | HOH1302 |
| T | HOH1303 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG T 1203 |
| Chain | Residue |
| A | HOH2198 |
| T | A14 |
| T | HOH1304 |
| T | HOH1305 |
| T | HOH1306 |
| T | HOH1307 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG T 1204 |
| Chain | Residue |
| T | G26 |
| T | G43 |
| T | A44 |
| T | HOH1218 |
| T | HOH1308 |
| T | HOH1309 |
| T | HOH1310 |
| T | HOH1311 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG T 1205 |
| Chain | Residue |
| A | ASN713 |
| A | ASN718 |
| A | HOH2199 |
| T | C25 |
| T | HOH1312 |
| T | HOH1313 |
| T | HOH1314 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG T 1206 |
| Chain | Residue |
| T | U8 |
| T | A9 |
| T | HOH1315 |
| T | HOH1316 |
| T | HOH1317 |
| T | HOH1318 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG T 1207 |
| Chain | Residue |
| T | G16 |
| T | G19 |
| T | G59 |
| T | U60 |
| T | HOH1250 |
| T | HOH1319 |
| T | HOH1320 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG T 1208 |
| Chain | Residue |
| A | ASN703 |
| A | HOH2200 |
| A | HOH2201 |
| T | C13 |
| T | A14 |
| T | HOH1321 |
| T | HOH1322 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG T 1209 |
| Chain | Residue |
| T | U47 |
| T | C48 |
| T | G50 |
| T | HOH1323 |
| T | HOH1324 |
| T | HOH1325 |
| T | HOH1326 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG T 1210 |
| Chain | Residue |
| T | U8 |
| T | U12 |
| T | HOH1318 |
| T | HOH1327 |
| T | HOH1328 |
| T | HOH1329 |
| T | HOH1330 |
| site_id | BC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE MRC A 1993 |
| Chain | Residue |
| A | PRO56 |
| A | PRO57 |
| A | TYR58 |
| A | HIS64 |
| A | GLY66 |
| A | ASN70 |
| A | GLU554 |
| A | GLY555 |
| A | ASP557 |
| A | GLN558 |
| A | HIS585 |
| A | GLY586 |
| A | PHE587 |
| A | VAL588 |
| A | MET596 |
| A | SER597 |
| A | HOH2085 |
| A | HOH2116 |
| A | HOH2138 |
Functional Information from PROSITE/UniProt
| site_id | PS00178 |
| Number of Residues | 12 |
| Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PyaNGnLHMGHA |
| Chain | Residue | Details |
| A | PRO57-ALA68 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | ILE51 | |
| A | ASN62 | |
| A | ALA549 | |
| A | ASP550 | |
| A | TYR552 | |
| A | LEU553 | |
| A | LYS580 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY593 | |
| Chain | Residue | Details |
| A | TYR627 | |
| A | ASP635 | |
| Chain | Residue | Details |
| A | ALA881 | |
| A | GLU884 | |
| A | GLU901 | |
| A | HIS904 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a8h |
| Chain | Residue | Details |
| A | LYS595 | |
| A | LYS598 | |
