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1FDV

HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH NAD+

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
A0005496molecular_functionsteroid binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006694biological_processsteroid biosynthetic process
A0006703biological_processestrogen biosynthetic process
A0007040biological_processlysosome organization
A0007519biological_processskeletal muscle tissue development
A0008210biological_processestrogen metabolic process
A0010467biological_processgene expression
A0016491molecular_functionoxidoreductase activity
A0030283molecular_functiontestosterone dehydrogenase [NAD(P)+] activity
A0035410molecular_functionobsolete dihydrotestosterone 17-beta-dehydrogenase activity
A0036094molecular_functionsmall molecule binding
A0042803molecular_functionprotein homodimerization activity
A0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
A0047045molecular_functiontestosterone 17-beta-dehydrogenase (NADP+) activity
A0050661molecular_functionNADP binding
A0060348biological_processbone development
A0060612biological_processadipose tissue development
A0061370biological_processtestosterone biosynthetic process
A0070401molecular_functionNADP+ binding
A0071248biological_processcellular response to metal ion
A0072582molecular_function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
A1903924molecular_functionestradiol binding
B0003824molecular_functioncatalytic activity
B0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
B0005496molecular_functionsteroid binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006694biological_processsteroid biosynthetic process
B0006703biological_processestrogen biosynthetic process
B0007040biological_processlysosome organization
B0007519biological_processskeletal muscle tissue development
B0008210biological_processestrogen metabolic process
B0010467biological_processgene expression
B0016491molecular_functionoxidoreductase activity
B0030283molecular_functiontestosterone dehydrogenase [NAD(P)+] activity
B0035410molecular_functionobsolete dihydrotestosterone 17-beta-dehydrogenase activity
B0036094molecular_functionsmall molecule binding
B0042803molecular_functionprotein homodimerization activity
B0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
B0047045molecular_functiontestosterone 17-beta-dehydrogenase (NADP+) activity
B0050661molecular_functionNADP binding
B0060348biological_processbone development
B0060612biological_processadipose tissue development
B0061370biological_processtestosterone biosynthetic process
B0070401molecular_functionNADP+ binding
B0071248biological_processcellular response to metal ion
B0072582molecular_function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
B1903924molecular_functionestradiol binding
C0003824molecular_functioncatalytic activity
C0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
C0005496molecular_functionsteroid binding
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006694biological_processsteroid biosynthetic process
C0006703biological_processestrogen biosynthetic process
C0007040biological_processlysosome organization
C0007519biological_processskeletal muscle tissue development
C0008210biological_processestrogen metabolic process
C0010467biological_processgene expression
C0016491molecular_functionoxidoreductase activity
C0030283molecular_functiontestosterone dehydrogenase [NAD(P)+] activity
C0035410molecular_functionobsolete dihydrotestosterone 17-beta-dehydrogenase activity
C0036094molecular_functionsmall molecule binding
C0042803molecular_functionprotein homodimerization activity
C0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
C0047045molecular_functiontestosterone 17-beta-dehydrogenase (NADP+) activity
C0050661molecular_functionNADP binding
C0060348biological_processbone development
C0060612biological_processadipose tissue development
C0061370biological_processtestosterone biosynthetic process
C0070401molecular_functionNADP+ binding
C0071248biological_processcellular response to metal ion
C0072582molecular_function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
C1903924molecular_functionestradiol binding
D0003824molecular_functioncatalytic activity
D0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
D0005496molecular_functionsteroid binding
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0006694biological_processsteroid biosynthetic process
D0006703biological_processestrogen biosynthetic process
D0007040biological_processlysosome organization
D0007519biological_processskeletal muscle tissue development
D0008210biological_processestrogen metabolic process
D0010467biological_processgene expression
D0016491molecular_functionoxidoreductase activity
D0030283molecular_functiontestosterone dehydrogenase [NAD(P)+] activity
D0035410molecular_functionobsolete dihydrotestosterone 17-beta-dehydrogenase activity
D0036094molecular_functionsmall molecule binding
D0042803molecular_functionprotein homodimerization activity
D0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
D0047045molecular_functiontestosterone 17-beta-dehydrogenase (NADP+) activity
D0050661molecular_functionNADP binding
D0060348biological_processbone development
D0060612biological_processadipose tissue development
D0061370biological_processtestosterone biosynthetic process
D0070401molecular_functionNADP+ binding
D0071248biological_processcellular response to metal ion
D0072582molecular_function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
D1903924molecular_functionestradiol binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 A 401
ChainResidue
ASER12
AGLY13
AHIS17
AARG44

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 B 400
ChainResidue
CHIS17
CARG44
CTHR190
CPRO233
CSER12
CGLY13

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 C 403
ChainResidue
ASER11
AARG37
ATHR41
ANAD361

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 402
ChainResidue
CSER11
CARG37
CTHR41
CNAD363

site_idAC5
Number of Residues28
DetailsBINDING SITE FOR RESIDUE NAD A 361
ChainResidue
AGLY9
ACYS10
ASER11
ASER12
AGLY13
AILE14
AARG37
ALEU64
AASP65
AVAL66
AARG67
AASN90
AALA91
AGLY92
ALEU93
AVAL113
ATHR140
AGLY141
ATYR155
ACYS185
AGLY186
APRO187
AVAL188
ATHR190
APHE192
ALYS195
APHE226
CSO4403

site_idAC6
Number of Residues20
DetailsBINDING SITE FOR RESIDUE NAD B 364
ChainResidue
BGLY9
BCYS10
BSER11
BSER12
BARG37
BVAL66
BASN90
BALA91
BGLY92
BTHR140
BGLY141
BSER142
BTYR155
BLYS159
BCYS185
BGLY186
BPRO187
BVAL188
BTHR190
BPHE226

site_idAC7
Number of Residues30
DetailsBINDING SITE FOR RESIDUE NAD C 363
ChainResidue
CGLY9
CSER11
CSER12
CGLY13
CILE14
CARG37
CLEU64
CASP65
CVAL66
CASN90
CALA91
CGLY92
CLEU93
CVAL113
CTHR140
CGLY141
CTYR155
CLYS159
CCYS185
CGLY186
CPRO187
CVAL188
CTHR190
CPHE192
CPHE226
CHOH512
CHOH517
CHOH529
CHOH536
DSO4402

site_idAC8
Number of Residues21
DetailsBINDING SITE FOR RESIDUE NAD D 362
ChainResidue
DGLY9
DSER11
DSER12
DILE14
DARG37
DLEU64
DASP65
DVAL66
DASN90
DGLY92
DVAL113
DTHR140
DGLY141
DSER142
DLYS159
DCYS185
DGLY186
DPRO187
DVAL188
DTHR190
DHOH522

site_idCAT
Number of Residues3
DetailsCATALYTIC SITE.
ChainResidue
ASER142
ATYR155
ALYS159

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SvgglmglpfNdvYCASKFALeGLCeSLA
ChainResidueDetails
ASER142-ALA170

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
ACYS156
BCYS156
CCYS156
DCYS156

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:8805577
ChainResidueDetails
ACYS10
CVAL66
CVAL143
CPHE160
DCYS10
DVAL66
DVAL143
DPHE160
AVAL66
AVAL143
APHE160
BCYS10
BVAL66
BVAL143
BPHE160
CCYS10

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:8994190
ChainResidueDetails
AGLY135
BGLY135
CGLY135
DGLY135

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
AASN152
ALYS159

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
BASN152
BLYS159

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
CASN152
CLYS159

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
DASN152
DLYS159

site_idCSA5
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
ATYR155
ALYS159

site_idCSA6
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
BTYR155
BLYS159

site_idCSA7
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
CTYR155
CLYS159

site_idCSA8
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
DTYR155
DLYS159

226707

PDB entries from 2024-10-30

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