1FDJ
FRUCTOSE 1,6-BISPHOSPHATE ALDOLASE FROM RABBIT LIVER
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006000 | biological_process | fructose metabolic process |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0034451 | cellular_component | centriolar satellite |
| A | 0061609 | molecular_function | fructose-1-phosphate aldolase activity |
| B | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006000 | biological_process | fructose metabolic process |
| B | 0006094 | biological_process | gluconeogenesis |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0034451 | cellular_component | centriolar satellite |
| B | 0061609 | molecular_function | fructose-1-phosphate aldolase activity |
| C | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006000 | biological_process | fructose metabolic process |
| C | 0006094 | biological_process | gluconeogenesis |
| C | 0006096 | biological_process | glycolytic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0034451 | cellular_component | centriolar satellite |
| C | 0061609 | molecular_function | fructose-1-phosphate aldolase activity |
| D | 0004332 | molecular_function | fructose-bisphosphate aldolase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006000 | biological_process | fructose metabolic process |
| D | 0006094 | biological_process | gluconeogenesis |
| D | 0006096 | biological_process | glycolytic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0034451 | cellular_component | centriolar satellite |
| D | 0061609 | molecular_function | fructose-1-phosphate aldolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 5000 |
| Chain | Residue |
| A | ARG1258 |
| A | HOH5733 |
| B | LYS2012 |
| B | HOH6216 |
| site_id | AC2 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE 2FP A 5001 |
| Chain | Residue |
| A | GLU1189 |
| A | SER1271 |
| A | GLY1272 |
| A | GLY1273 |
| A | GLY1302 |
| A | ARG1303 |
| A | HOH5148 |
| A | HOH5209 |
| A | HOH5210 |
| A | HOH5303 |
| A | HOH5306 |
| A | HOH5458 |
| A | HOH5626 |
| A | HOH5629 |
| A | HOH5682 |
| A | HOH5708 |
| A | HOH5709 |
| A | HOH5710 |
| A | HOH5711 |
| A | HOH5713 |
| A | HOH5714 |
| A | HOH5715 |
| A | HOH5716 |
| A | HOH5717 |
| A | ARG1042 |
| A | LYS1107 |
| A | LYS1146 |
| A | ARG1148 |
| A | GLU1187 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 6000 |
| Chain | Residue |
| A | LYS1012 |
| B | GLN2202 |
| B | ARG2258 |
| B | HOH6004 |
| B | HOH6034 |
| B | HOH6540 |
| site_id | AC4 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE 2FP B 6001 |
| Chain | Residue |
| B | ASP2033 |
| B | LYS2107 |
| B | LYS2146 |
| B | ARG2148 |
| B | GLU2187 |
| B | GLU2189 |
| B | LYS2229 |
| B | LEU2270 |
| B | SER2271 |
| B | GLY2272 |
| B | GLY2273 |
| B | SER2300 |
| B | GLY2302 |
| B | ARG2303 |
| B | 13P6002 |
| B | G3P6003 |
| B | HOH6781 |
| B | HOH6783 |
| B | HOH6785 |
| B | HOH6787 |
| B | HOH6788 |
| B | HOH6793 |
| B | HOH6795 |
| B | HOH6797 |
| B | HOH6799 |
| B | HOH6800 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 13P B 6002 |
| Chain | Residue |
| B | ALA2031 |
| B | LYS2229 |
| B | LEU2270 |
| B | SER2271 |
| B | GLY2273 |
| B | SER2300 |
| B | TYR2301 |
| B | GLY2302 |
| B | ARG2303 |
| B | 2FP6001 |
| B | HOH6784 |
| B | HOH6786 |
| B | HOH6788 |
| B | HOH6793 |
| B | HOH6800 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE G3P B 6003 |
| Chain | Residue |
| B | THR2038 |
| B | LYS2146 |
| B | ARG2148 |
| B | 2FP6001 |
| B | HOH6315 |
| B | HOH6373 |
| B | HOH6503 |
| B | HOH6781 |
| B | HOH6783 |
| B | HOH6785 |
| B | HOH6788 |
| B | HOH6790 |
| B | HOH6792 |
| B | HOH6799 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 7000 |
| Chain | Residue |
| C | GLN3202 |
| C | ARG3258 |
| C | HOH7098 |
| D | LYS4012 |
| site_id | AC8 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 13P C 7001 |
| Chain | Residue |
| C | ASP3033 |
| C | GLU3034 |
| C | LYS3146 |
| C | LYS3229 |
| C | SER3271 |
| C | GLY3272 |
| C | GLY3273 |
| C | GLY3302 |
| C | ARG3303 |
| C | HOH7702 |
| C | HOH7703 |
| C | HOH7890 |
| C | HOH7892 |
| C | HOH7893 |
| C | HOH7894 |
| C | HOH7895 |
| C | HOH7896 |
| C | HOH7898 |
| C | HOH7901 |
| C | ALA3031 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 8000 |
| Chain | Residue |
| C | LYS3012 |
| D | GLN4202 |
| D | THR4254 |
| D | ARG4258 |
| D | HOH8047 |
| D | HOH8048 |
| site_id | BC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 13P D 8001 |
| Chain | Residue |
| D | ALA4031 |
| D | ASP4033 |
| D | GLU4034 |
| D | ARG4042 |
| D | SER4271 |
| D | GLY4272 |
| D | GLY4273 |
| D | GLY4302 |
| D | ARG4303 |
| D | TYR4363 |
| D | HOH8091 |
| D | HOH8916 |
| D | HOH8918 |
| D | HOH8920 |
| D | HOH8922 |
| D | HOH8925 |
| D | HOH8927 |
| D | HOH8928 |
| site_id | BC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 13P D 8002 |
| Chain | Residue |
| D | ARG4042 |
| D | GLU4187 |
| D | LEU4270 |
| D | SER4271 |
| D | GLY4272 |
| D | GLY4273 |
| D | GLY4302 |
| D | ARG4303 |
| D | TYR4363 |
| D | HOH8693 |
| D | HOH8887 |
| D | HOH8915 |
| D | HOH8918 |
| D | HOH8919 |
| D | HOH8920 |
| D | HOH8922 |
| D | HOH8924 |
| D | HOH8928 |
Functional Information from PROSITE/UniProt
| site_id | PS00158 |
| Number of Residues | 11 |
| Details | ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VyLEGtLLKPN |
| Chain | Residue | Details |
| A | VAL1221-ASN1231 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P00883","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Schiff-base intermediate with dihydroxyacetone-P","evidences":[{"source":"UniProtKB","id":"P00883","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00883","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Necessary for preference for fructose 1,6-bisphosphate over fructose 1-phosphate","evidences":[{"source":"UniProtKB","id":"P00883","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"Q91Y97","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q91Y97","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 24 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P05062","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P05062","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P00884","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ald |
| Chain | Residue | Details |
| A | LYS1229 | |
| A | ASP1033 | |
| A | GLU1187 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ald |
| Chain | Residue | Details |
| B | LYS2229 | |
| B | ASP2033 | |
| B | GLU2187 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ald |
| Chain | Residue | Details |
| C | GLU3187 | |
| C | ASP3033 | |
| C | LYS3229 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ald |
| Chain | Residue | Details |
| D | GLU4187 | |
| D | ASP4033 | |
| D | LYS4229 |
