1FBA

THE CRYSTAL STRUCTURE OF FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE FROM DROSOPHILA MELANOGASTER AT 2.5 ANGSTROMS RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004332	molecular_function	fructose-bisphosphate aldolase activity
A	0005829	cellular_component	cytosol
A	0006001	biological_process	fructose catabolic process
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0007498	biological_process	mesoderm development
A	0016829	molecular_function	lyase activity
A	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
A	0030018	cellular_component	Z disc
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0031430	cellular_component	M band
A	0042593	biological_process	glucose homeostasis
A	0061609	molecular_function	fructose-1-phosphate aldolase activity
A	0061621	biological_process	canonical glycolysis
B	0004332	molecular_function	fructose-bisphosphate aldolase activity
B	0005829	cellular_component	cytosol
B	0006001	biological_process	fructose catabolic process
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0007498	biological_process	mesoderm development
B	0016829	molecular_function	lyase activity
B	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
B	0030018	cellular_component	Z disc
B	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
B	0031430	cellular_component	M band
B	0042593	biological_process	glucose homeostasis
B	0061609	molecular_function	fructose-1-phosphate aldolase activity
B	0061621	biological_process	canonical glycolysis
C	0004332	molecular_function	fructose-bisphosphate aldolase activity
C	0005829	cellular_component	cytosol
C	0006001	biological_process	fructose catabolic process
C	0006094	biological_process	gluconeogenesis
C	0006096	biological_process	glycolytic process
C	0007498	biological_process	mesoderm development
C	0016829	molecular_function	lyase activity
C	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
C	0030018	cellular_component	Z disc
C	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
C	0031430	cellular_component	M band
C	0042593	biological_process	glucose homeostasis
C	0061609	molecular_function	fructose-1-phosphate aldolase activity
C	0061621	biological_process	canonical glycolysis
D	0004332	molecular_function	fructose-bisphosphate aldolase activity
D	0005829	cellular_component	cytosol
D	0006001	biological_process	fructose catabolic process
D	0006094	biological_process	gluconeogenesis
D	0006096	biological_process	glycolytic process
D	0007498	biological_process	mesoderm development
D	0016829	molecular_function	lyase activity
D	0019682	biological_process	glyceraldehyde-3-phosphate metabolic process
D	0030018	cellular_component	Z disc
D	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
D	0031430	cellular_component	M band
D	0042593	biological_process	glucose homeostasis
D	0061609	molecular_function	fructose-1-phosphate aldolase activity
D	0061621	biological_process	canonical glycolysis

Functional Information from PDB Data

site_id	FBA
Number of Residues	1
Details

Chain	Residue
A	LYS229

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site_id	FBB
Number of Residues	1
Details

Chain	Residue
B	LYS229

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site_id	FBC
Number of Residues	1
Details

Chain	Residue
C	LYS229

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site_id	FBD
Number of Residues	1
Details

Chain	Residue
D	LYS229

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Functional Information from PROSITE/UniProt

site_id	PS00158
Number of Residues	11
Details	ALDOLASE_CLASS_I Fructose-bisphosphate aldolase class-I active site. VyLEGtLLKPN

Chain	Residue	Details
A	VAL221-ASN231

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	PRO188
B	PRO188
C	PRO188
D	PRO188

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Schiff-base intermediate with dihydroxyacetone-P

Chain	Residue	Details
A	PRO230
B	PRO230
C	PRO230
D	PRO230

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
A	ARG56
A	TRP147
B	ARG56
B	TRP147
C	ARG56
C	TRP147
D	ARG56
D	TRP147

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site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylthreonine => ECO:0000269|PubMed:1959612, ECO:0000269|PubMed:3918528

Chain	Residue	Details
A	THR2
B	THR2
C	THR2
D	THR2

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
A	GLU187
A	LYS229
A	ASP33

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site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
B	GLU187
B	LYS229
B	ASP33

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site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
C	GLU187
C	LYS229
C	ASP33

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site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1ald

Chain	Residue	Details
D	GLU187
D	LYS229
D	ASP33

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