1F6Y

MAD CRYSTAL STRUCTURE ANALYSIS OF METHYLTETRAHYDROFOLATE: CORRINOID/IRON-SULFUR PROTEIN METHYLTRANSFERASE (METR)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0008168	molecular_function	methyltransferase activity
A	0008705	molecular_function	methionine synthase activity
A	0009086	biological_process	methionine biosynthetic process
A	0015977	biological_process	carbon fixation
A	0016740	molecular_function	transferase activity
A	0031419	molecular_function	cobalamin binding
A	0032259	biological_process	methylation
A	0042558	biological_process	pteridine-containing compound metabolic process
A	0046653	biological_process	tetrahydrofolate metabolic process
A	0046872	molecular_function	metal ion binding
A	0050667	biological_process	homocysteine metabolic process
A	0071267	biological_process	L-methionine salvage
A	0102036	molecular_function	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0008168	molecular_function	methyltransferase activity
B	0008705	molecular_function	methionine synthase activity
B	0009086	biological_process	methionine biosynthetic process
B	0015977	biological_process	carbon fixation
B	0016740	molecular_function	transferase activity
B	0031419	molecular_function	cobalamin binding
B	0032259	biological_process	methylation
B	0042558	biological_process	pteridine-containing compound metabolic process
B	0046653	biological_process	tetrahydrofolate metabolic process
B	0046872	molecular_function	metal ion binding
B	0050667	biological_process	homocysteine metabolic process
B	0071267	biological_process	L-methionine salvage
B	0102036	molecular_function	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:17172470, ECO:0000269|PubMed:22419154, ECO:0007744|PDB:4DJE, ECO:0007744|PDB:4DJF

Chain	Residue	Details
A	ASN96
A	ASP160
A	ASN199
A	ARG207
B	ASN96
B	ASP160
B	ASN199
B	ARG207

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:17172470, ECO:0000269|PubMed:22419154

Chain	Residue	Details
A	LYS184
A	GLY222
A	MET224
B	LYS184
B	GLY222
B	MET224

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:17172470, ECO:0000269|PubMed:22419154, ECO:0007744|PDB:4DJF

Chain	Residue	Details
A	GLN202
B	GLN202

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site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Transition state stabilizer

Chain	Residue	Details
A	ASN199
B	ASN199

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