1EV9

RAT GLUTATHIONE S-TRANSFERASE A1-1 MUTANT W21F WITH GSO3 BOUND

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004601	molecular_function	peroxidase activity
A	0004769	molecular_function	steroid Delta-isomerase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0009617	biological_process	response to bacterium
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016853	molecular_function	isomerase activity
A	0030855	biological_process	epithelial cell differentiation
A	0035634	biological_process	response to stilbenoid
A	0035731	molecular_function	dinitrosyl-iron complex binding
A	0042178	biological_process	xenobiotic catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0043295	molecular_function	glutathione binding
A	0098869	biological_process	cellular oxidant detoxification
A	1901687	biological_process	glutathione derivative biosynthetic process
C	0004364	molecular_function	glutathione transferase activity
C	0004601	molecular_function	peroxidase activity
C	0004769	molecular_function	steroid Delta-isomerase activity
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006693	biological_process	prostaglandin metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0006805	biological_process	xenobiotic metabolic process
C	0009617	biological_process	response to bacterium
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0016853	molecular_function	isomerase activity
C	0030855	biological_process	epithelial cell differentiation
C	0035634	biological_process	response to stilbenoid
C	0035731	molecular_function	dinitrosyl-iron complex binding
C	0042178	biological_process	xenobiotic catabolic process
C	0042803	molecular_function	protein homodimerization activity
C	0043295	molecular_function	glutathione binding
C	0098869	biological_process	cellular oxidant detoxification
C	1901687	biological_process	glutathione derivative biosynthetic process
D	0004364	molecular_function	glutathione transferase activity
D	0004601	molecular_function	peroxidase activity
D	0004769	molecular_function	steroid Delta-isomerase activity
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006693	biological_process	prostaglandin metabolic process
D	0006749	biological_process	glutathione metabolic process
D	0006805	biological_process	xenobiotic metabolic process
D	0009617	biological_process	response to bacterium
D	0016491	molecular_function	oxidoreductase activity
D	0016740	molecular_function	transferase activity
D	0016853	molecular_function	isomerase activity
D	0030855	biological_process	epithelial cell differentiation
D	0035634	biological_process	response to stilbenoid
D	0035731	molecular_function	dinitrosyl-iron complex binding
D	0042178	biological_process	xenobiotic catabolic process
D	0042803	molecular_function	protein homodimerization activity
D	0043295	molecular_function	glutathione binding
D	0098869	biological_process	cellular oxidant detoxification
D	1901687	biological_process	glutathione derivative biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 260

Chain	Residue
A	THR77
A	ASP85
A	MET86
A	ARG89

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 261

Chain	Residue
C	LYS84
C	ASP85
C	MET86
C	ARG89

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 262

Chain	Residue
D	MET86
D	ARG89
C	THR77

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GTS A 230

Chain	Residue
A	TYR9
A	ARG15
A	LYS45
A	ASP53
A	GLN54
A	VAL55
A	GLN67
A	THR68
A	ASP101
A	ARG131
A	PHE220
A	HOH458
A	HOH468
A	HOH470
A	HOH472
A	HOH554
A	HOH686

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GTS C 240

Chain	Residue
C	TYR9
C	PHE10
C	ARG15
C	LYS45
C	ASP53
C	GLN54
C	VAL55
C	GLN67
C	THR68
D	ASP101
D	ARG131

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GTS D 250

Chain	Residue
C	ASP101
C	ARG131
D	TYR9
D	PHE10
D	ARG15
D	LYS45
D	ASP53
D	GLN54
D	VAL55
D	PRO56
D	GLN67
D	THR68
D	HOH593

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	Domain: {"description":"GST N-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	369
Details	Domain: {"description":"GST C-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11119643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P30115","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
A	TYR9

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
C	TYR9

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
D	TYR9

---