1EUU
SIALIDASE OR NEURAMINIDASE, LARGE 68KD FORM
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004308 | molecular_function | exo-alpha-sialidase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0005737 | cellular_component | cytoplasm |
A | 0005975 | biological_process | carbohydrate metabolic process |
A | 0006689 | biological_process | ganglioside catabolic process |
A | 0009313 | biological_process | oligosaccharide catabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0052794 | molecular_function | exo-alpha-(2->3)-sialidase activity |
A | 0052795 | molecular_function | exo-alpha-(2->6)-sialidase activity |
A | 0052796 | molecular_function | exo-alpha-(2->8)-sialidase activity |
Functional Information from PDB Data
site_id | ACT |
Number of Residues | 9 |
Details | ACTIVE SITE INCLUDES TWO RESIDUES (TYR 740, GLU 756) FROM A SYMMETRY RELATED UNIT. |
Chain | Residue |
A | GLN224 |
A | GLY245 |
A | ALA250 |
A | GLY292 |
A | ASN311 |
A | PHE318 |
A | ALA619 |
A | TYR635 |
A | ALA637 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000250 |
Chain | Residue | Details |
A | ASP92 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: Nucleophile => ECO:0000255 |
Chain | Residue | Details |
A | GLU260 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | ACT_SITE: Nucleophile |
Chain | Residue | Details |
A | TYR370 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ARG68 | |
A | ARG276 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | a catalytic site defined by CSA, PubMed 14580216, 8591030, 12812490, 15130470, 15527797 |
Chain | Residue | Details |
A | ASP92 | |
A | TYR370 | |
A | GLU260 |
site_id | MCSA1 |
Number of Residues | 3 |
Details | M-CSA 835 |
Chain | Residue | Details |
A | ASP92 | activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
A | GLU260 | activator, increase nucleophilicity, promote heterolysis, proton acceptor, proton donor |
A | TYR370 | covalently attached, nucleofuge, nucleophile, proton acceptor, proton donor |