1ETH

TRIACYLGLYCEROL LIPASE/COLIPASE COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004465	molecular_function	lipoprotein lipase activity
A	0004806	molecular_function	triacylglycerol lipase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0008970	molecular_function	phospholipase A1 activity
A	0016042	biological_process	lipid catabolic process
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
A	0019433	biological_process	triglyceride catabolic process
A	0034375	biological_process	high-density lipoprotein particle remodeling
A	0042572	biological_process	retinol metabolic process
A	0042632	biological_process	cholesterol homeostasis
A	0046872	molecular_function	metal ion binding
A	0047376	molecular_function	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
A	0052689	molecular_function	carboxylic ester hydrolase activity
B	0001523	biological_process	retinoid metabolic process
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0006629	biological_process	lipid metabolic process
B	0007586	biological_process	digestion
B	0008047	molecular_function	enzyme activator activity
B	0016042	biological_process	lipid catabolic process
B	0035473	molecular_function	lipase binding
B	0043085	biological_process	positive regulation of catalytic activity
C	0004465	molecular_function	lipoprotein lipase activity
C	0004806	molecular_function	triacylglycerol lipase activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006629	biological_process	lipid metabolic process
C	0006633	biological_process	fatty acid biosynthetic process
C	0008970	molecular_function	phospholipase A1 activity
C	0016042	biological_process	lipid catabolic process
C	0016298	molecular_function	lipase activity
C	0016787	molecular_function	hydrolase activity
C	0019433	biological_process	triglyceride catabolic process
C	0034375	biological_process	high-density lipoprotein particle remodeling
C	0042572	biological_process	retinol metabolic process
C	0042632	biological_process	cholesterol homeostasis
C	0046872	molecular_function	metal ion binding
C	0047376	molecular_function	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
C	0052689	molecular_function	carboxylic ester hydrolase activity
D	0001523	biological_process	retinoid metabolic process
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0006629	biological_process	lipid metabolic process
D	0007586	biological_process	digestion
D	0008047	molecular_function	enzyme activator activity
D	0016042	biological_process	lipid catabolic process
D	0035473	molecular_function	lipase binding
D	0043085	biological_process	positive regulation of catalytic activity

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VHVIGHSLGS

Chain	Residue	Details
A	VAL147-SER156

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site_id	PS00121
Number of Residues	9
Details	COLIPASE_1 Colipase signature. YgvYYkCpC

Chain	Residue	Details
B	TYR55-CYS63

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Nucleophile"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"380992","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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