1ETH

TRIACYLGLYCEROL LIPASE/COLIPASE COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004806	molecular_function	triglyceride lipase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006629	biological_process	lipid metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
A	0042572	biological_process	retinol metabolic process
A	0046872	molecular_function	metal ion binding
A	0047376	molecular_function	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
A	0052689	molecular_function	carboxylic ester hydrolase activity
B	0005576	cellular_component	extracellular region
B	0007586	biological_process	digestion
B	0008047	molecular_function	enzyme activator activity
B	0016042	biological_process	lipid catabolic process
B	0032094	biological_process	response to food
B	0035473	molecular_function	lipase binding
B	0043085	biological_process	positive regulation of catalytic activity
C	0004806	molecular_function	triglyceride lipase activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006629	biological_process	lipid metabolic process
C	0016042	biological_process	lipid catabolic process
C	0016298	molecular_function	lipase activity
C	0016787	molecular_function	hydrolase activity
C	0042572	biological_process	retinol metabolic process
C	0046872	molecular_function	metal ion binding
C	0047376	molecular_function	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
C	0052689	molecular_function	carboxylic ester hydrolase activity
D	0005576	cellular_component	extracellular region
D	0007586	biological_process	digestion
D	0008047	molecular_function	enzyme activator activity
D	0016042	biological_process	lipid catabolic process
D	0032094	biological_process	response to food
D	0035473	molecular_function	lipase binding
D	0043085	biological_process	positive regulation of catalytic activity

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VHVIGHSLGS

Chain	Residue	Details
A	VAL147-SER156

---

site_id	PS00121
Number of Residues	9
Details	COLIPASE_1 Colipase signature. YgvYYkCpC

Chain	Residue	Details
B	TYR55-CYS63

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile

Chain	Residue	Details
A	SER153
C	SER153

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	ASP177
A	HIS264
C	ASP177
C	HIS264

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING:

Chain	Residue	Details
A	GLU188
A	ARG191
A	ASP193
A	ASP196
C	GLU188
C	ARG191
C	ASP193
C	ASP196

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:380992

Chain	Residue	Details
A	ASN167
C	ASN167

---