Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1EQU

TYPE 1 17-BETA HYDROXYSTEROID DEHYDROGENASE EQUILIN COMPLEXED WITH NADP+

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
A0005496molecular_functionsteroid binding
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006694biological_processsteroid biosynthetic process
A0006703biological_processestrogen biosynthetic process
A0007040biological_processlysosome organization
A0007519biological_processskeletal muscle tissue development
A0008210biological_processestrogen metabolic process
A0010467biological_processgene expression
A0016491molecular_functionoxidoreductase activity
A0030283molecular_functiontestosterone dehydrogenase [NAD(P)+] activity
A0035410molecular_functionobsolete dihydrotestosterone 17-beta-dehydrogenase activity
A0036094molecular_functionsmall molecule binding
A0042803molecular_functionprotein homodimerization activity
A0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
A0047045molecular_functiontestosterone 17-beta-dehydrogenase (NADP+) activity
A0050661molecular_functionNADP binding
A0060348biological_processbone development
A0060612biological_processadipose tissue development
A0061370biological_processtestosterone biosynthetic process
A0070401molecular_functionNADP+ binding
A0071248biological_processcellular response to metal ion
A0072582molecular_function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
A1903924molecular_functionestradiol binding
B0003824molecular_functioncatalytic activity
B0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
B0005496molecular_functionsteroid binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006694biological_processsteroid biosynthetic process
B0006703biological_processestrogen biosynthetic process
B0007040biological_processlysosome organization
B0007519biological_processskeletal muscle tissue development
B0008210biological_processestrogen metabolic process
B0010467biological_processgene expression
B0016491molecular_functionoxidoreductase activity
B0030283molecular_functiontestosterone dehydrogenase [NAD(P)+] activity
B0035410molecular_functionobsolete dihydrotestosterone 17-beta-dehydrogenase activity
B0036094molecular_functionsmall molecule binding
B0042803molecular_functionprotein homodimerization activity
B0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
B0047045molecular_functiontestosterone 17-beta-dehydrogenase (NADP+) activity
B0050661molecular_functionNADP binding
B0060348biological_processbone development
B0060612biological_processadipose tissue development
B0061370biological_processtestosterone biosynthetic process
B0070401molecular_functionNADP+ binding
B0071248biological_processcellular response to metal ion
B0072582molecular_function17-beta-hydroxysteroid dehydrogenase (NADP+) activity
B1903924molecular_functionestradiol binding
Functional Information from PDB Data
site_idAC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE NAP A 328
ChainResidue
ASER11
AALA91
AGLY92
ALEU93
ATHR140
AGLY141
ASER142
ATYR155
AVAL188
ATHR190
AALA191
ASER12
APHE192
AEQI329
AGLY13
AILE14
AARG37
ALEU64
AASP65
AVAL66
AASN90

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE EQI A 329
ChainResidue
ASER142
AVAL143
AGLY144
ALEU149
ATYR155
APHE192
ATYR218
AHIS221
AARG258
AGLU282
ANAP328

site_idAC3
Number of Residues23
DetailsBINDING SITE FOR RESIDUE NAP B 328
ChainResidue
BGLY9
BSER11
BSER12
BILE14
BARG37
BLEU64
BASP65
BVAL66
BARG67
BASN90
BALA91
BGLY92
BLEU93
BVAL113
BTHR140
BGLY141
BSER142
BTYR155
BLYS159
BCYS185
BVAL188
BTHR190
BMET193

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SvgglmglpfNdvYCASKFALeGLCeSLA
ChainResidueDetails
ASER142-ALA170

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
ACYS156
BCYS156

site_idSWS_FT_FI2
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:8805577
ChainResidueDetails
ACYS10
AVAL66
AVAL143
APHE160
BCYS10
BVAL66
BVAL143
BPHE160

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:8994190
ChainResidueDetails
AGLY135
BGLY135

Catalytic Information from CSA
site_idCSA1
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
AASN152
ALYS159

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
BASN152
BLYS159

site_idCSA3
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
ATYR155
ALYS159

site_idCSA4
Number of Residues2
DetailsAnnotated By Reference To The Literature 1qsg
ChainResidueDetails
BTYR155
BLYS159

226707

PDB entries from 2024-10-30

PDB statisticsPDBj update infoContact PDBjnumon