1EO3

INHIBITION OF ECORV ENDONUCLEASE BY DEOXYRIBO-3'-S-PHOSPHOROTHIOLATES: A HIGH RESOLUTION X-RAY CRYSTALLOGRAPHIC STUDY

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Functional Information from GO Data

ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0046872molecular_functionmetal ion binding
A0009036molecular_functiontype II site-specific deoxyribonuclease activity
A0009307biological_processDNA restriction-modification system
B0003677molecular_functionDNA binding
B0046872molecular_functionmetal ion binding
B0009036molecular_functiontype II site-specific deoxyribonuclease activity
B0009307biological_processDNA restriction-modification system
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC15BINDING SITE FOR RESIDUE MG A 501
ChainResidue
AGLU45
AASP74
AHOH610
AHOH666
AHOH708

AC24BINDING SITE FOR RESIDUE MG A 502
ChainResidue
AASP74
AILE91
AHOH611
CHOH27

AC36BINDING SITE FOR RESIDUE MG B 503
ChainResidue
BGLU45
BASP74
BHOH618
BHOH619
BHOH622
BHOH668

AC45BINDING SITE FOR RESIDUE MG B 504
ChainResidue
BASP74
BILE91
BHOH623
BHOH625
BHOH699

AC56BINDING SITE FOR RESIDUE ACY A 601
ChainResidue
ATYR18
AASP19
AVAL20
APHE47
ATYR163
AVAL166

AC66BINDING SITE FOR RESIDUE ACY B 602
ChainResidue
BTYR18
BASP19
BVAL20
BPHE44
BTYR163
BVAL166

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
TSP_1eo3_C_6163'-THIO-THYMIDINE-5'-PHOSPHATE binding site
ChainResidueligand
CDA5TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
CDA7TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
DDA7-DT8TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
AGLN69-TYR72TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
AGLY108-GLY109TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
ASER112-PHE113TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
AASN120TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
ATHR186TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
AASN188TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
BTHR186TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE

TSP_1eo3_D_6153'-THIO-THYMIDINE-5'-PHOSPHATE binding site
ChainResidueligand
CDA7-DT8TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
DDA5TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
DDA7TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
BGLN69-TYR72TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
BGLY108-GLY109TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
BSER112-PHE113TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
BASN120TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
BTHR186TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE
BASN188TSP: 3'-THIO-THYMIDINE-5'-PHOSPHATE

ACY_1eo3_A_6018ACETIC ACID binding site
ChainResidueligand
ATYR18-VAL20ACY: ACETIC ACID
AILE43-PHE44ACY: ACETIC ACID
APHE47ACY: ACETIC ACID
ATYR163ACY: ACETIC ACID
AVAL166ACY: ACETIC ACID

ACY_1eo3_B_6028ACETIC ACID binding site
ChainResidueligand
BASN15ACY: ACETIC ACID
BTYR18-VAL20ACY: ACETIC ACID
BPHE44ACY: ACETIC ACID
BPHE47ACY: ACETIC ACID
BTYR163ACY: ACETIC ACID
BVAL166ACY: ACETIC ACID

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
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Catalytic Information from CSA

site_idNumber of ResiduesDetails