1EK5

STRUCTURE OF HUMAN UDP-GALACTOSE 4-EPIMERASE IN COMPLEX WITH NAD+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003974	molecular_function	UDP-N-acetylglucosamine 4-epimerase activity
A	0003978	molecular_function	UDP-glucose 4-epimerase activity
A	0005829	cellular_component	cytosol
A	0006012	biological_process	galactose metabolic process
A	0016853	molecular_function	isomerase activity
A	0019388	biological_process	galactose catabolic process
A	0033499	biological_process	galactose catabolic process via UDP-galactose
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NAD A 400

Chain	Residue
A	GLY9
A	ALA38
A	MET65
A	ASP66
A	ILE67
A	PHE88
A	GLY90
A	LYS92
A	SER130
A	SER131
A	TYR157
A	GLY12
A	LYS161
A	TYR185
A	PHE186
A	PRO188
A	ASN206
A	HOH605
A	HOH606
A	HOH625
A	HOH631
A	HOH653
A	TYR13
A	HOH655
A	HOH656
A	HOH658
A	HOH660
A	ILE14
A	ASP33
A	ASN34
A	PHE35
A	HIS36
A	ASN37

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193, ECO:0000303|PubMed:15175331

Chain	Residue	Details
A	TYR157

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site_id	SWS_FT_FI2
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193

Chain	Residue	Details
A	GLY12
A	ASP33
A	ASP66
A	PHE88
A	LYS92
A	LYS161
A	ASN206
A	ASN224
A	ARG239

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10801319, ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193, ECO:0000303|PubMed:15175331

Chain	Residue	Details
A	SER132

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10801319

Chain	Residue	Details
A	TYR185

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site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:11279032, ECO:0000269|PubMed:11279193

Chain	Residue	Details
A	ARG300

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	LYS161
A	TYR157
A	SER132

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	LYS161
A	SER130
A	TYR157
A	ASN108

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	TYR141
A	LYS161

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site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1eq2

Chain	Residue	Details
A	LYS161
A	TYR157

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