1EIN

THE STRUCTURAL ORIGINS OF INTERFACIAL ACTIVATION IN THERMOMYCES (HUMICOLA) LANUGINOSA LIPASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004806	molecular_function	triacylglycerol lipase activity
A	0006629	biological_process	lipid metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
B	0004806	molecular_function	triacylglycerol lipase activity
B	0006629	biological_process	lipid metabolic process
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
C	0004806	molecular_function	triacylglycerol lipase activity
C	0006629	biological_process	lipid metabolic process
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PLC A 601

Chain	Residue
A	SER83
C	PLC801
A	ARG84
A	TRP89
A	ASN92
A	SER146
A	VAL203
A	ILE255
B	PLC701
C	TRP89

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PLC B 701

Chain	Residue
A	TRP89
A	PLC601
B	SER83
B	ASN92
B	VAL203
B	ILE255
C	ILE255
C	PLC801

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site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PLC C 801

Chain	Residue
A	ILE255
A	PLC601
B	TRP89
B	PLC701
C	ARG84
C	ASN92
C	VAL203
C	ILE255

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Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VVFTGHSLGG

Chain	Residue	Details
A	VAL140-GLY149

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"8014587","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"8014587","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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