Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004487 | molecular_function | methylenetetrahydrofolate dehydrogenase (NAD+) activity |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006164 | biological_process | purine nucleotide biosynthetic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0009113 | biological_process | purine nucleobase biosynthetic process |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE NAD A 321 |
| Chain | Residue |
| A | ASN184 |
| A | PRO254 |
| A | PHE274 |
| A | CYS276 |
| A | THR295 |
| A | HOH322 |
| A | HOH326 |
| A | HOH327 |
| A | ARG185 |
| A | SER186 |
| A | VAL189 |
| A | VAL207 |
| A | ASP208 |
| A | VAL209 |
| A | GLY252 |
| A | VAL253 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS150 | |
| Chain | Residue | Details |
| A | ARG185 | |
| A | ASP208 | |
| A | PHE274 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1a4i |
| Chain | Residue | Details |
| A | THR57 | |
