1EBF
HOMOSERINE DEHYDROGENASE FROM S. CEREVISIAE COMPLEX WITH NAD+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004412 | molecular_function | homoserine dehydrogenase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006520 | biological_process | amino acid metabolic process |
| A | 0009067 | biological_process | aspartate family amino acid biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0009090 | biological_process | homoserine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0004412 | molecular_function | homoserine dehydrogenase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006520 | biological_process | amino acid metabolic process |
| B | 0009067 | biological_process | aspartate family amino acid biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0009090 | biological_process | homoserine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 2104 |
| Chain | Residue |
| A | GLU143 |
| A | VAL146 |
| A | GLY147 |
| A | ALA148 |
| A | LEU150 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 2114 |
| Chain | Residue |
| B | LEU150 |
| B | GLU143 |
| B | VAL146 |
| B | GLY147 |
| B | ALA148 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE NAD A 2109 |
| Chain | Residue |
| A | ILE11 |
| A | ALA13 |
| A | GLY14 |
| A | VAL15 |
| A | VAL16 |
| A | GLU40 |
| A | ALA41 |
| A | THR93 |
| A | SER94 |
| A | PRO115 |
| A | ASN116 |
| A | GLY340 |
| A | HOH2123 |
| A | HOH2186 |
Functional Information from PROSITE/UniProt
| site_id | PS01042 |
| Number of Residues | 23 |
| Details | HOMOSER_DHGENASE Homoserine dehydrogenase signature. AkklGYTep.DPrdDLnGlDvarK |
| Chain | Residue | Details |
| A | ALA201-LYS223 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS223 | |
| B | LYS223 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10700284 |
| Chain | Residue | Details |
| A | ILE11 | |
| A | THR93 | |
| A | LYS117 | |
| A | GLU208 | |
| B | ILE11 | |
| B | THR93 | |
| B | LYS117 | |
| B | GLU208 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| A | LYS290 | |
| B | LYS290 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | a catalytic site defined by CSA, PubMed 10700284 |
| Chain | Residue | Details |
| A | LYS223 | |
| A | ASP219 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 521 |
| Chain | Residue | Details |
| A | ASP219 | electrostatic stabiliser |
| A | LYS223 | proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 521 |
| Chain | Residue | Details |
| B | ASP219 | electrostatic stabiliser |
| B | LYS223 | proton shuttle (general acid/base) |
