1E7Y
ACTIVE SITE MUTANT (D177->N) OF GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES COMPLEXED WITH SUBSTRATE AND NADPH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004345 | molecular_function | glucose-6-phosphate dehydrogenase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006006 | biological_process | glucose metabolic process |
| A | 0006098 | biological_process | pentose-phosphate shunt |
| A | 0009051 | biological_process | pentose-phosphate shunt, oxidative branch |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00966, ECO:0000269|PubMed:9485426 |
| Chain | Residue | Details |
| A | THR241 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00966, ECO:0000269|PubMed:11106478, ECO:0000269|PubMed:11320304, ECO:0000269|PubMed:9485426 |
| Chain | Residue | Details |
| A | GLY13 | |
| A | GLN47 | |
| A | VAL86 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00966, ECO:0000269|PubMed:11320304 |
| Chain | Residue | Details |
| A | PRO149 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:11106478 |
| Chain | Residue | Details |
| A | TYR179 | |
| A | GLU183 | |
| A | VAL217 | |
| A | MET236 | |
| A | ARG339 | |
| A | GLN344 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dpg |
| Chain | Residue | Details |
| A | ASN177 | |
| A | HIS240 |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 843 |
| Chain | Residue | Details |
| A | ASN177 | modifies pKa |
| A | HIS178 | transition state stabiliser |
| A | HIS240 | proton acceptor, proton donor |
