Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1E6Y

Methyl-coenzyme M reductase from Methanosarcina barkeri

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0015948	biological_process	methanogenesis
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
A	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
B	0005737	cellular_component	cytoplasm
B	0015948	biological_process	methanogenesis
B	0016740	molecular_function	transferase activity
B	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
C	0005737	cellular_component	cytoplasm
C	0015948	biological_process	methanogenesis
C	0016740	molecular_function	transferase activity
C	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
D	0005737	cellular_component	cytoplasm
D	0015948	biological_process	methanogenesis
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding
D	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
E	0005737	cellular_component	cytoplasm
E	0015948	biological_process	methanogenesis
E	0016740	molecular_function	transferase activity
E	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
F	0005737	cellular_component	cytoplasm
F	0015948	biological_process	methanogenesis
F	0016740	molecular_function	transferase activity
F	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	38
Details	BINDING SITE FOR RESIDUE F43 A 2570

Chain	Residue
A	ALA1158
A	HOH2478
A	HOH2479
A	HOH2480
A	HOH2481
D	HOH2427
D	GLY4339
D	GLY4340
D	VAL4341
D	GLY4342
D	PHE4343
A	VAL1159
D	THR4344
D	GLN4345
D	TYR4346
D	PHE4416
D	GLY4417
D	GLY4462
D	PHE4463
D	COM5572
E	SER5363
E	ILE5364
A	VAL1160
E	TYR5365
F	LEU6118
F	SER6119
F	GLY6120
F	ALA6154
F	THR6155
F	VAL6156
F	HIS6157
F	HIS6159
A	GLN1161
A	GLN1244
A	MET1247
A	ALA1257
A	HOH2224
A	HOH2477

site_id	AC2
Number of Residues	23
Details	BINDING SITE FOR RESIDUE TP7 A 2571

Chain	Residue
A	ARG1284
A	LEU1333
A	MET1337
A	SER1338
A	PHE1343
A	PHE1463
A	MET1500
A	ASN1501
A	VAL1502
A	HOH2275
A	HOH2482
A	HOH2483
A	HOH2484
A	HOH2485
A	HOH2486
B	PHE2360
B	TYR2365
B	GLY2367
B	HIS2377
B	VAL2378
D	ARG4239
D	LYS4270
D	MHS4271

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE COM A 2572

Chain	Residue
A	TYR1346
A	PHE1463
A	PHE1464
A	HOH2487
B	PHE2359
B	TYR2365
C	LEU3118
C	ARG3121
D	F435570

site_id	AC4
Number of Residues	38
Details	BINDING SITE FOR RESIDUE F43 D 5570

Chain	Residue
D	HOH2514
D	HOH2515
D	ALA4158
D	VAL4159
D	VAL4160
D	GLN4161
D	GLN4244
D	MET4247
D	ALA4257
A	GLY1339
A	GLY1340
A	VAL1341
A	GLY1342
A	PHE1343
A	THR1344
A	GLN1345
A	TYR1346
A	PHE1416
A	GLY1417
A	GLY1462
A	PHE1463
A	HOH2353
A	COM2572
B	SER2363
B	ILE2364
B	TYR2365
C	LEU3118
C	SER3119
C	GLY3120
C	ALA3154
C	THR3155
C	VAL3156
C	HIS3157
C	HIS3159
D	HOH2285
D	HOH2511
D	HOH2512
D	HOH2513

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE TP7 D 5571

Chain	Residue
A	ARG1239
A	LYS1270
A	MHS1271
D	HOH2366
D	HOH2461
D	HOH2517
D	HOH2518
D	HOH2519
D	HOH2520
D	ARG4284
D	LEU4333
D	MET4337
D	SER4338
D	PHE4463
D	MET4500
D	ASN4501
D	VAL4502
E	PHE5360
E	TYR5365
E	GLY5367
E	HIS5377
E	VAL5378

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE COM D 5572

Chain	Residue
A	F432570
D	HOH2521
D	TYR4346
D	PHE4463
D	PHE4464
E	PHE5359
E	TYR5365
F	LEU6118
F	ARG6121

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 2573

Chain	Residue
A	LYS1379
A	LYS1382
A	THR1437
A	GLY1438
A	ARG1519
A	HOH2362
A	HOH2488
E	GLY5068

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 2574

Chain	Residue
A	MHS1271
A	LEU1274
A	VAL1275
A	SER1276
A	GLU1279
A	HOH2489
E	LYS5062
E	MET5168

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 5573

Chain	Residue
B	GLY2068
B	ARG2069
D	HOH2522
D	LYS4379
D	LYS4382
D	THR4437
D	GLY4438
D	ARG4519

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"11023796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E6Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"11023796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E6Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"11023796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E6Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11023796","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E6Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Pros-methylhistidine","evidences":[{"source":"PubMed","id":"11023796","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"5-methylarginine","evidences":[{"source":"PubMed","id":"11023796","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"1-thioglycine","evidences":[{"source":"PubMed","id":"11023796","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"(Z)-2,3-didehydroaspartate","evidences":[{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"S-methylcysteine","evidences":[{"source":"PubMed","id":"11023796","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1mro

Chain	Residue	Details
A	ASP1521
A	GLY1485
B	TYR2365

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1mro

Chain	Residue	Details
D	ASP4521
D	GLY4485
E	TYR5365

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)