Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1E6E

ADRENODOXIN REDUCTASE/ADRENODOXIN COMPLEX OF MITOCHONDRIAL P450 SYSTEMS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004324	molecular_function	ferredoxin-NADP+ reductase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0006744	biological_process	ubiquinone biosynthetic process
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0022900	biological_process	electron transport chain
A	0050660	molecular_function	flavin adenine dinucleotide binding
A	0050661	molecular_function	NADP binding
B	0051536	molecular_function	iron-sulfur cluster binding
B	0051537	molecular_function	2 iron, 2 sulfur cluster binding
B	0140647	biological_process	P450-containing electron transport chain
C	0004324	molecular_function	ferredoxin-NADP+ reductase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006629	biological_process	lipid metabolic process
C	0006694	biological_process	steroid biosynthetic process
C	0006744	biological_process	ubiquinone biosynthetic process
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0022900	biological_process	electron transport chain
C	0050660	molecular_function	flavin adenine dinucleotide binding
C	0050661	molecular_function	NADP binding
D	0051536	molecular_function	iron-sulfur cluster binding
D	0051537	molecular_function	2 iron, 2 sulfur cluster binding
D	0140647	biological_process	P450-containing electron transport chain

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 3001

Chain	Residue
A	CYS74
A	PHE76
A	SER423
A	PHE424
A	SER425
A	HOH2016
A	HOH2020
A	HOH2127

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 3004

Chain	Residue
A	ARG73
A	SER71

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 3005

Chain	Residue
A	ARG334
C	ARG278
C	HOH2083
C	HOH2089

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 3002

Chain	Residue
C	CYS74
C	PHE76
C	SER423
C	PHE424
C	SER425
C	HOH2014
C	HOH2111
C	HOH2123

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 3003

Chain	Residue
C	SER71
C	ASP72
C	ARG73

site_id	AC6
Number of Residues	31
Details	BINDING SITE FOR RESIDUE FAD A 461

Chain	Residue
A	GLY13
A	GLY15
A	PRO16
A	ALA17
A	GLU38
A	LYS39
A	GLY45
A	LEU46
A	GLY50
A	VAL58
A	VAL80
A	VAL82
A	SER101
A	TYR102
A	GLY103
A	GLU105
A	ARG124
A	VAL127
A	ASP159
A	ILE336
A	GLY366
A	TRP367
A	GLY374
A	VAL375
A	ILE376
A	THR379
A	HOH2046
A	HOH2047
A	HOH2124
A	HOH2125
A	HOH2126

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES B 129

Chain	Residue
B	GLY44
B	CYS46
B	GLY48
B	LEU50
B	CYS52
B	CYS55
B	CYS92

site_id	AC8
Number of Residues	34
Details	BINDING SITE FOR RESIDUE FAD C 461

Chain	Residue
C	GLY13
C	GLY15
C	PRO16
C	ALA17
C	GLU38
C	LYS39
C	GLN40
C	GLY45
C	LEU46
C	GLY50
C	HIS55
C	VAL58
C	VAL80
C	VAL82
C	SER101
C	TYR102
C	GLY103
C	GLU105
C	ASP159
C	ILE336
C	GLY366
C	TRP367
C	GLY374
C	VAL375
C	ILE376
C	THR379
C	HOH2009
C	HOH2019
C	HOH2021
C	HOH2041
C	HOH2118
C	HOH2119
C	HOH2120
C	HOH2122

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES D 129

Chain	Residue
D	GLY48
D	LEU50
D	CYS52
D	CYS55
D	CYS92
D	GLY44
D	CYS46

Functional Information from PROSITE/UniProt

site_id	PS00814
Number of Residues	11
Details	ADX Adrenodoxin family, iron-sulfur binding region signature. CegTlACSTCH

Chain	Residue	Details
B	CYS46-HIS56

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10369776","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10998235","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P22570","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	104
Details	Domain: {"description":"2Fe-2S ferredoxin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00465","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P46656","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P46656","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P10109","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	a catalytic site defined by CSA, PubMed 11053423, 12069587, 10998235

Chain	Residue	Details
A	THR377
A	THR377
A	ILE376
A	ILE376
A	HIS55
A	ASP159

site_id	CSA2
Number of Residues	6
Details	a catalytic site defined by CSA, PubMed 11053423, 12069587, 10998235

Chain	Residue	Details
C	THR377
C	THR377
C	ILE376
C	ILE376
C	HIS55
C	ASP159

site_id	MCSA1
Number of Residues	4
Details	M-CSA 142

Chain	Residue	Details
A	HIS55	electrostatic stabiliser, hydrogen bond acceptor
A	ASP159	electrostatic stabiliser, hydrogen bond acceptor
A	ILE376	polar interaction, single electron acceptor, single electron donor, single electron relay
A	THR377	polar interaction, single electron acceptor, single electron donor, single electron relay

site_id	MCSA2
Number of Residues	4
Details	M-CSA 142

Chain	Residue	Details
C	HIS55	electrostatic stabiliser, hydrogen bond acceptor
C	ASP159	electrostatic stabiliser, hydrogen bond acceptor
C	ILE376	polar interaction, single electron acceptor, single electron donor, single electron relay
C	THR377	polar interaction, single electron acceptor, single electron donor, single electron relay

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)