1E5Q
Ternary complex of saccharopine reductase from Magnaporthe grisea, NADPH and saccharopine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004753 | molecular_function | saccharopine dehydrogenase activity |
| A | 0004755 | molecular_function | saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019878 | biological_process | lysine biosynthetic process via aminoadipic acid |
| B | 0004753 | molecular_function | saccharopine dehydrogenase activity |
| B | 0004755 | molecular_function | saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009085 | biological_process | lysine biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019878 | biological_process | lysine biosynthetic process via aminoadipic acid |
| C | 0004753 | molecular_function | saccharopine dehydrogenase activity |
| C | 0004755 | molecular_function | saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009085 | biological_process | lysine biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0019878 | biological_process | lysine biosynthetic process via aminoadipic acid |
| D | 0004753 | molecular_function | saccharopine dehydrogenase activity |
| D | 0004755 | molecular_function | saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009085 | biological_process | lysine biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0019878 | biological_process | lysine biosynthetic process via aminoadipic acid |
| E | 0004753 | molecular_function | saccharopine dehydrogenase activity |
| E | 0004755 | molecular_function | saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0008652 | biological_process | amino acid biosynthetic process |
| E | 0009085 | biological_process | lysine biosynthetic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0019878 | biological_process | lysine biosynthetic process via aminoadipic acid |
| F | 0004753 | molecular_function | saccharopine dehydrogenase activity |
| F | 0004755 | molecular_function | saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0008652 | biological_process | amino acid biosynthetic process |
| F | 0009085 | biological_process | lysine biosynthetic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0019878 | biological_process | lysine biosynthetic process via aminoadipic acid |
| G | 0004753 | molecular_function | saccharopine dehydrogenase activity |
| G | 0004755 | molecular_function | saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0008652 | biological_process | amino acid biosynthetic process |
| G | 0009085 | biological_process | lysine biosynthetic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0019878 | biological_process | lysine biosynthetic process via aminoadipic acid |
| H | 0004753 | molecular_function | saccharopine dehydrogenase activity |
| H | 0004755 | molecular_function | saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0008652 | biological_process | amino acid biosynthetic process |
| H | 0009085 | biological_process | lysine biosynthetic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0019878 | biological_process | lysine biosynthetic process via aminoadipic acid |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NDP A 500 |
| Chain | Residue |
| A | SER11 |
| A | VAL56 |
| A | LEU75 |
| A | ILE76 |
| A | PRO77 |
| A | TYR78 |
| A | PHE80 |
| A | THR98 |
| A | SER99 |
| A | GLY124 |
| A | LEU125 |
| A | GLY12 |
| A | ASP126 |
| A | PRO127 |
| A | TRP174 |
| A | SER175 |
| A | VAL399 |
| A | SHR501 |
| A | HOH2062 |
| A | HOH2293 |
| A | HOH2294 |
| A | HOH2295 |
| A | PHE13 |
| A | HOH2296 |
| A | HOH2297 |
| A | HOH2298 |
| A | HOH2299 |
| A | VAL14 |
| A | CYS33 |
| A | ARG34 |
| A | THR35 |
| A | LEU54 |
| A | ASP55 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SHR A 501 |
| Chain | Residue |
| A | TYR78 |
| A | SER99 |
| A | TYR100 |
| A | ASP126 |
| A | CYS155 |
| A | GLY156 |
| A | GLY157 |
| A | TRP174 |
| A | ARG224 |
| A | THR245 |
| A | ARG247 |
| A | NDP500 |
| A | HOH2085 |
| A | HOH2300 |
| A | HOH2301 |
| A | HOH2302 |
| A | HOH2303 |
| site_id | AC3 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NDP B 500 |
| Chain | Residue |
| B | SER11 |
| B | GLY12 |
| B | PHE13 |
| B | VAL14 |
| B | CYS33 |
| B | ARG34 |
| B | THR35 |
| B | LEU54 |
| B | ASP55 |
| B | VAL56 |
| B | ASN57 |
| B | LEU75 |
| B | ILE76 |
| B | PRO77 |
| B | TYR78 |
| B | PHE80 |
| B | THR98 |
| B | SER99 |
| B | GLY124 |
| B | LEU125 |
| B | ASP126 |
| B | PRO127 |
| B | TRP174 |
| B | SER175 |
| B | VAL399 |
| B | SHR501 |
| B | HOH2289 |
| B | HOH2290 |
| B | HOH2291 |
| B | HOH2292 |
| B | HOH2293 |
| B | HOH2294 |
| B | HOH2295 |
| B | HOH2296 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SHR B 501 |
| Chain | Residue |
| B | HOH2297 |
| B | HOH2298 |
| B | TYR78 |
| B | SER99 |
| B | TYR100 |
| B | ASP126 |
| B | CYS155 |
| B | GLY156 |
| B | GLY157 |
| B | TRP174 |
| B | ARG224 |
| B | THR245 |
| B | ARG247 |
| B | NDP500 |
| B | HOH2103 |
| B | HOH2150 |
| B | HOH2160 |
| site_id | AC5 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NDP C 500 |
| Chain | Residue |
| C | SER11 |
| C | GLY12 |
| C | PHE13 |
| C | VAL14 |
| C | CYS33 |
| C | ARG34 |
| C | THR35 |
| C | LEU54 |
| C | ASP55 |
| C | VAL56 |
| C | ASN57 |
| C | LEU75 |
| C | ILE76 |
| C | PRO77 |
| C | TYR78 |
| C | PHE80 |
| C | THR98 |
| C | SER99 |
| C | LEU125 |
| C | ASP126 |
| C | PRO127 |
| C | TRP174 |
| C | SER175 |
| C | VAL399 |
| C | SHR501 |
| C | HOH2339 |
| C | HOH2340 |
| C | HOH2341 |
| C | HOH2342 |
| C | HOH2343 |
| C | HOH2344 |
| C | HOH2345 |
| C | HOH2346 |
| C | HOH2347 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE SHR C 501 |
| Chain | Residue |
| C | TYR78 |
| C | SER99 |
| C | TYR100 |
| C | ASP126 |
| C | CYS155 |
| C | GLY156 |
| C | GLY157 |
| C | TRP174 |
| C | ARG224 |
| C | THR245 |
| C | ARG247 |
| C | NDP500 |
| C | HOH2141 |
| C | HOH2173 |
| C | HOH2348 |
| C | HOH2349 |
| site_id | AC7 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NDP D 500 |
| Chain | Residue |
| D | SER11 |
| D | GLY12 |
| D | PHE13 |
| D | VAL14 |
| D | CYS33 |
| D | ARG34 |
| D | THR35 |
| D | LEU54 |
| D | ASP55 |
| D | VAL56 |
| D | ASN57 |
| D | LEU75 |
| D | ILE76 |
| D | PRO77 |
| D | TYR78 |
| D | PHE80 |
| D | THR98 |
| D | SER99 |
| D | LEU125 |
| D | ASP126 |
| D | PRO127 |
| D | TRP174 |
| D | SER175 |
| D | VAL399 |
| D | SHR501 |
| D | HOH2308 |
| D | HOH2309 |
| D | HOH2310 |
| D | HOH2311 |
| D | HOH2312 |
| D | HOH2313 |
| D | HOH2314 |
| D | HOH2315 |
| site_id | AC8 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SHR D 501 |
| Chain | Residue |
| D | TYR78 |
| D | SER99 |
| D | TYR100 |
| D | ASP126 |
| D | CYS155 |
| D | GLY156 |
| D | GLY157 |
| D | TRP174 |
| D | ARG224 |
| D | THR245 |
| D | ARG247 |
| D | NDP500 |
| D | HOH2087 |
| D | HOH2143 |
| D | HOH2316 |
| D | HOH2317 |
| D | HOH2318 |
| site_id | AC9 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NDP E 500 |
| Chain | Residue |
| E | SER11 |
| E | GLY12 |
| E | PHE13 |
| E | VAL14 |
| E | CYS33 |
| E | ARG34 |
| E | THR35 |
| E | LEU54 |
| E | ASP55 |
| E | VAL56 |
| E | ASN57 |
| E | LEU75 |
| E | ILE76 |
| E | PRO77 |
| E | TYR78 |
| E | PHE80 |
| E | THR98 |
| E | SER99 |
| E | GLY124 |
| E | LEU125 |
| E | ASP126 |
| E | PRO127 |
| E | TRP174 |
| E | SER175 |
| E | VAL399 |
| E | SHR501 |
| E | HOH2284 |
| E | HOH2285 |
| E | HOH2286 |
| E | HOH2288 |
| E | HOH2289 |
| E | HOH2290 |
| E | HOH2291 |
| E | HOH2292 |
| E | HOH2293 |
| site_id | BC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SHR E 501 |
| Chain | Residue |
| E | TYR78 |
| E | SER99 |
| E | TYR100 |
| E | ASP126 |
| E | CYS155 |
| E | GLY156 |
| E | GLY157 |
| E | TRP174 |
| E | ARG224 |
| E | THR245 |
| E | ARG247 |
| E | NDP500 |
| E | HOH2112 |
| E | HOH2151 |
| E | HOH2294 |
| E | HOH2295 |
| E | HOH2296 |
| site_id | BC2 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NDP F 500 |
| Chain | Residue |
| F | SER11 |
| F | GLY12 |
| F | PHE13 |
| F | VAL14 |
| F | CYS33 |
| F | ARG34 |
| F | THR35 |
| F | LEU54 |
| F | ASP55 |
| F | VAL56 |
| F | LEU75 |
| F | ILE76 |
| F | PRO77 |
| F | TYR78 |
| F | PHE80 |
| F | THR98 |
| F | SER99 |
| F | GLY124 |
| F | LEU125 |
| F | ASP126 |
| F | PRO127 |
| F | TRP174 |
| F | SER175 |
| F | VAL399 |
| F | SHR501 |
| F | HOH2065 |
| F | HOH2331 |
| F | HOH2332 |
| F | HOH2333 |
| F | HOH2334 |
| F | HOH2335 |
| F | HOH2336 |
| F | HOH2337 |
| F | HOH2338 |
| site_id | BC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SHR F 501 |
| Chain | Residue |
| F | TYR78 |
| F | SER99 |
| F | TYR100 |
| F | ASP126 |
| F | CYS155 |
| F | GLY156 |
| F | GLY157 |
| F | TRP174 |
| F | ARG224 |
| F | THR245 |
| F | ARG247 |
| F | NDP500 |
| F | HOH2091 |
| F | HOH2159 |
| F | HOH2339 |
| F | HOH2340 |
| F | HOH2341 |
| site_id | BC4 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE NDP G 500 |
| Chain | Residue |
| G | SER11 |
| G | GLY12 |
| G | PHE13 |
| G | VAL14 |
| G | CYS33 |
| G | ARG34 |
| G | THR35 |
| G | LEU54 |
| G | ASP55 |
| G | VAL56 |
| G | ASN57 |
| G | LEU75 |
| G | ILE76 |
| G | PRO77 |
| G | TYR78 |
| G | PHE80 |
| G | THR98 |
| G | SER99 |
| G | LEU125 |
| G | ASP126 |
| G | PRO127 |
| G | TRP174 |
| G | SER175 |
| G | VAL399 |
| G | SHR501 |
| G | HOH2048 |
| G | HOH2064 |
| G | HOH2325 |
| G | HOH2326 |
| G | HOH2327 |
| G | HOH2328 |
| G | HOH2329 |
| G | HOH2330 |
| G | HOH2331 |
| G | HOH2332 |
| G | HOH2333 |
| site_id | BC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SHR G 501 |
| Chain | Residue |
| G | TYR78 |
| G | SER99 |
| G | TYR100 |
| G | ASP126 |
| G | CYS155 |
| G | GLY156 |
| G | GLY157 |
| G | TRP174 |
| G | ARG224 |
| G | THR245 |
| G | ARG247 |
| G | NDP500 |
| G | HOH2091 |
| G | HOH2151 |
| G | HOH2158 |
| G | HOH2334 |
| G | HOH2335 |
| site_id | BC6 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NDP H 500 |
| Chain | Residue |
| H | SER11 |
| H | GLY12 |
| H | PHE13 |
| H | VAL14 |
| H | CYS33 |
| H | ARG34 |
| H | THR35 |
| H | LEU54 |
| H | ASP55 |
| H | VAL56 |
| H | ASN57 |
| H | LEU75 |
| H | ILE76 |
| H | PRO77 |
| H | TYR78 |
| H | PHE80 |
| H | THR98 |
| H | SER99 |
| H | GLY124 |
| H | LEU125 |
| H | ASP126 |
| H | PRO127 |
| H | TRP174 |
| H | SER175 |
| H | VAL399 |
| H | SHR501 |
| H | HOH2259 |
| H | HOH2260 |
| H | HOH2261 |
| H | HOH2262 |
| H | HOH2264 |
| H | HOH2265 |
| H | HOH2266 |
| H | HOH2267 |
| site_id | BC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SHR H 501 |
| Chain | Residue |
| H | TYR78 |
| H | SER99 |
| H | TYR100 |
| H | ASP126 |
| H | CYS155 |
| H | GLY156 |
| H | GLY157 |
| H | TRP174 |
| H | ARG224 |
| H | THR245 |
| H | ARG247 |
| H | NDP500 |
| H | HOH2097 |
| H | HOH2143 |
| H | HOH2152 |
| H | HOH2268 |
| H | HOH2269 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 128 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11080625","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E5Q","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11080625 |
| Chain | Residue | Details |
| A | ASP126 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11080625 |
| Chain | Residue | Details |
| B | ASP126 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11080625 |
| Chain | Residue | Details |
| C | ASP126 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11080625 |
| Chain | Residue | Details |
| D | ASP126 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11080625 |
| Chain | Residue | Details |
| E | ASP126 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11080625 |
| Chain | Residue | Details |
| F | ASP126 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11080625 |
| Chain | Residue | Details |
| G | ASP126 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 11080625 |
| Chain | Residue | Details |
| H | ASP126 |
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 618 |
| Chain | Residue | Details |
| A | ASP126 |
| site_id | MCSA2 |
| Number of Residues | 1 |
| Details | M-CSA 618 |
| Chain | Residue | Details |
| B | ASP126 |
| site_id | MCSA3 |
| Number of Residues | 1 |
| Details | M-CSA 618 |
| Chain | Residue | Details |
| C | ASP126 |
| site_id | MCSA4 |
| Number of Residues | 1 |
| Details | M-CSA 618 |
| Chain | Residue | Details |
| D | ASP126 |
| site_id | MCSA5 |
| Number of Residues | 1 |
| Details | M-CSA 618 |
| Chain | Residue | Details |
| E | ASP126 |
| site_id | MCSA6 |
| Number of Residues | 1 |
| Details | M-CSA 618 |
| Chain | Residue | Details |
| F | ASP126 |
| site_id | MCSA7 |
| Number of Residues | 1 |
| Details | M-CSA 618 |
| Chain | Residue | Details |
| G | ASP126 |
| site_id | MCSA8 |
| Number of Residues | 1 |
| Details | M-CSA 618 |
| Chain | Residue | Details |
| H | ASP126 |
