1E50

AML1/CBFbeta complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
B	0003713	molecular_function	transcription coactivator activity
B	0005634	cellular_component	nucleus
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
D	0003713	molecular_function	transcription coactivator activity
D	0005634	cellular_component	nucleus
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0006355	biological_process	regulation of DNA-templated transcription
F	0003713	molecular_function	transcription coactivator activity
F	0005634	cellular_component	nucleus
G	0003677	molecular_function	DNA binding
G	0003700	molecular_function	DNA-binding transcription factor activity
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0006355	biological_process	regulation of DNA-templated transcription
H	0003713	molecular_function	transcription coactivator activity
H	0005634	cellular_component	nucleus
Q	0003677	molecular_function	DNA binding
Q	0003700	molecular_function	DNA-binding transcription factor activity
Q	0005524	molecular_function	ATP binding
Q	0005634	cellular_component	nucleus
Q	0006355	biological_process	regulation of DNA-templated transcription
R	0003677	molecular_function	DNA binding
R	0003700	molecular_function	DNA-binding transcription factor activity
R	0005524	molecular_function	ATP binding
R	0005634	cellular_component	nucleus
R	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
A	ASN112
E	GLU116
E	ARG139
E	VAL170
G	ASN112
G	GLU116
G	ARG139
G	VAL170
Q	ASN112
Q	GLU116
Q	ARG139
A	GLU116
Q	VAL170
R	ASN112
R	GLU116
R	ARG139
R	VAL170
A	ARG139
A	VAL170
C	ASN112
C	GLU116
C	ARG139
C	VAL170
E	ASN112

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site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Breakpoint for translocation to form AML1-EMV-1 (or AML1-EAP) in CML and T-MDS, to form AML1-MTG8 (ETO) in AML-M2, to form AML1-CBFA2T3 in therapy-related myeloid malignancies, to form AML1-MECOM in CML and to form type I MACROD1-RUNX1 fusion protein

Chain	Residue	Details
A	ARG177
C	ARG177
E	ARG177
G	ARG177
Q	ARG177
R	ARG177

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