Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1E3U

MAD structure of OXA10 class D beta-lactamase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008658	molecular_function	penicillin binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0071555	biological_process	cell wall organization
B	0005886	cellular_component	plasma membrane
B	0008658	molecular_function	penicillin binding
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0042597	cellular_component	periplasmic space
B	0046677	biological_process	response to antibiotic
B	0071555	biological_process	cell wall organization
C	0005886	cellular_component	plasma membrane
C	0008658	molecular_function	penicillin binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0042597	cellular_component	periplasmic space
C	0046677	biological_process	response to antibiotic
C	0071555	biological_process	cell wall organization
D	0005886	cellular_component	plasma membrane
D	0008658	molecular_function	penicillin binding
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0042597	cellular_component	periplasmic space
D	0046677	biological_process	response to antibiotic
D	0071555	biological_process	cell wall organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AUC E 1

Chain	Residue
A	ALA66
A	SER67
A	PHE69
A	LYS70
A	ASN73
A	PHE120
A	TRP154
A	HOH401
A	HOH558

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE AUC E 2

Chain	Residue
B	ALA66
B	SER67
B	PHE69
B	LYS70
B	ASN73
B	PHE120
B	TRP154
B	HOH569

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE AUC E 3

Chain	Residue
C	LYS70
C	ALA116
C	VAL117
C	TRP154
C	HOH434
C	AUC302

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE AUC E 4

Chain	Residue
B	LYS95
B	HOH515
C	ALA66
C	SER67
C	LYS70
C	ASN73
C	PHE120
C	TRP154
C	AUC301

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE AUC E 5

Chain	Residue
C	GLN133
C	HOH410
C	EDO308

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE AUC E 6

Chain	Residue
D	ALA66
D	SER67
D	LYS70
D	ASN73
D	PHE120
D	TRP154
D	AUC302
D	HOH542

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE AUC E 7

Chain	Residue
D	LYS70
D	ALA116
D	VAL117
D	TRP154
D	HOH454
D	AUC301

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE AUC E 8

Chain	Residue
D	GLN133
D	HOH452
D	HOH539

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E 9

Chain	Residue
A	SER115
A	THR206
A	GLY207
A	PHE208
A	ARG250
A	HOH500
A	HOH469
A	HOH411
A	HOH498

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 10

Chain	Residue
A	ARG131
A	LYS134
A	TYR135

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 11

Chain	Residue
A	ARG160
A	HOH542

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 12

Chain	Residue
A	ILE22
C	SER33
C	ALA36
C	VAL37
C	ASN38
C	EDO307

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 E 13

Chain	Residue
B	SER115
B	LYS205
B	THR206
B	GLY207
B	PHE208
B	ARG250
B	HOH464
B	HOH577
B	HOH450

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 14

Chain	Residue
B	MET99
B	LYS100
B	GLN101

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 15

Chain	Residue
B	GLU35
B	SER245
B	LYS246
B	HOH432
B	HOH401
B	HOH433

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 E 16

Chain	Residue
B	PRO198
B	GLU199
B	LEU201
B	GLU227
B	GLU229
D	THR107
D	ARG109
B	HOH560

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 E 17

Chain	Residue
C	SER67
C	THR206
C	GLY207
C	PHE208
C	ARG250
C	HOH505
B	LYS95

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 18

Chain	Residue
A	HOH425
A	HOH436
C	SER181
C	LYS182
C	HOH517
C	HOH514

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 19

Chain	Residue
A	LYS95
D	SER67
D	THR206
D	GLY207
D	PHE208
D	ARG250

site_id	CC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 E 20

Chain	Residue
B	GLU183
B	HOH516
B	HOH466
D	SER181
D	LYS182
D	HOH464
D	HOH561
D	HOH506

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 21

Chain	Residue
D	THR213
D	SER215
D	ASN216
D	HOH523
D	HOH501

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 22

Chain	Residue
A	GLY128
A	GLU129
A	VAL130
A	HOH518
A	HOH402
A	HOH526

site_id	CC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 E 23

Chain	Residue
A	THR107
A	ARG109
C	PRO198
C	GLU199
C	LEU201
C	GLU227
C	GLU229
C	HOH452
A	HOH553
A	HOH508

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO E 24

Chain	Residue
C	GLU195
C	TYR200
C	HOH612

site_id	CC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO E 25

Chain	Residue
C	ASN29
C	PHE32
C	VAL37
C	ASN38
C	GLY39
C	ASN54
C	HOH408
A	SO4305
C	HOH441

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 26

Chain	Residue
B	ASN29
B	VAL37
B	ASN38
B	GLY39
B	ASN54
B	HOH565

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO E 27

Chain	Residue
B	GLU261

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 28

Chain	Residue
B	THR107
B	ARG109
D	PRO198
D	GLU199
D	GLU229
D	HOH433

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 29

Chain	Residue
B	THR80
B	ARG131
B	LYS134
B	TYR135
B	HOH493

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO E 30

Chain	Residue
A	GLU199
A	GLU227
A	GLU229
C	THR107
C	HOH438
A	HOH447
A	HOH520

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 31

Chain	Residue
C	ILE146
C	SER147
C	GLY148
C	GLY149
C	ILE150
C	AUC303

site_id	DC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO E 32

Chain	Residue
A	ALA36
A	PRO217
A	ASP240
A	ASP242
A	HOH409
A	HOH413
A	HOH434

site_id	DC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO E 33

Chain	Residue
B	GLU195
B	TYR200
B	VAL202
B	MET258
B	GLU259
B	ILE263
B	HOH416

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 34

Chain	Residue
B	PRO217
B	ASP240
B	HOH453
B	HOH403
B	HOH402

site_id	DC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO E 35

Chain	Residue
B	ASN143
B	ASN145

Functional Information from PROSITE/UniProt

site_id	PS00337
Number of Residues	11
Details	BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnAI

Chain	Residue	Details
D	PRO65-ILE75
A	PRO65-ILE75

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2WGI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"11188693","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11724923","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19860471","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1E4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K55","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K56","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K57","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1K6S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RL3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
D	SER67

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
A	SER67

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
B	SER67

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1m6k

Chain	Residue	Details
C	SER67

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)