1E2X
FadR, fatty acid responsive transcription factor from E. coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000062 | molecular_function | fatty-acyl-CoA binding |
| A | 0000987 | molecular_function | cis-regulatory region sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006631 | biological_process | fatty acid metabolic process |
| A | 0019217 | biological_process | regulation of fatty acid metabolic process |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0045723 | biological_process | positive regulation of fatty acid biosynthetic process |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A4001 |
| Chain | Residue |
| A | ARG114 |
| A | THR115 |
| A | ARG118 |
| A | GLN119 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A4002 |
| Chain | Residue |
| A | GLY79 |
| A | ASN81 |
| A | HOH2155 |
| A | HOH2156 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Domain: {"description":"HTH gntR-type","evidences":[{"source":"HAMAP-Rule","id":"MF_00696","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"HAMAP-Rule","id":"MF_00696","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PubMed","id":"11279025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11296236","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11296236","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
