1E2X

FadR, fatty acid responsive transcription factor from E. coli

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000062	molecular_function	fatty-acyl-CoA binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0019217	biological_process	regulation of fatty acid metabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0045723	biological_process	positive regulation of fatty acid biosynthetic process
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A4001

Chain	Residue
A	ARG114
A	THR115
A	ARG118
A	GLN119

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A4002

Chain	Residue
A	GLY79
A	ASN81
A	HOH2155
A	HOH2156

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	DNA_BIND: H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00696

Chain	Residue	Details
A	ARG35-ARG54

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site_id	SWS_FT_FI2
Number of Residues	35
Details	DNA_BIND: H-T-H motif => ECO:0000269|PubMed:11279025, ECO:0000269|PubMed:11296236

Chain	Residue	Details
A	ARG35-LYS70

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:11296236

Chain	Residue	Details
A	ASN100
A	VAL104
A	ARG214
A	GLY220

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