1E2A

ENZYME IIA FROM THE LACTOSE SPECIFIC PTS FROM LACTOCOCCUS LACTIS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0009401	biological_process	phosphoenolpyruvate-dependent sugar phosphotransferase system
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
B	0005737	cellular_component	cytoplasm
B	0009401	biological_process	phosphoenolpyruvate-dependent sugar phosphotransferase system
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
C	0005737	cellular_component	cytoplasm
C	0009401	biological_process	phosphoenolpyruvate-dependent sugar phosphotransferase system
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 106

Chain	Residue
A	ASP81
A	HOH128
A	HOH129
B	ASP81
B	HOH116
C	ASP81

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000305|PubMed:9261069

Chain	Residue	Details
A	HIS78
B	HIS78
C	HIS78

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:9261069

Chain	Residue	Details
A	ASP81
B	ASP81
C	ASP81

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site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: Phosphohistidine; by HPr => ECO:0000255|PROSITE-ProRule:PRU00418, ECO:0000305|PubMed:9261069

Chain	Residue	Details
A	HIS78
B	HIS78
C	HIS78

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 514

Chain	Residue	Details
A	HIS78	covalent catalysis, electrostatic stabiliser
A	GLN80	electrostatic stabiliser
A	HIS82	electrostatic stabiliser

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site_id	MCSA2
Number of Residues	3
Details	M-CSA 514

Chain	Residue	Details
B	HIS78	covalent catalysis, electrostatic stabiliser
B	GLN80	electrostatic stabiliser
B	HIS82	electrostatic stabiliser

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site_id	MCSA3
Number of Residues	3
Details	M-CSA 514

Chain	Residue	Details
C	HIS78	covalent catalysis, electrostatic stabiliser
C	GLN80	electrostatic stabiliser
C	HIS82	electrostatic stabiliser

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