1DYT
X-ray crystal structure of ECP (RNase 3) at 1.75 A
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001530 | molecular_function | lipopolysaccharide binding |
A | 0002227 | biological_process | innate immune response in mucosa |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0004519 | molecular_function | endonuclease activity |
A | 0004540 | molecular_function | RNA nuclease activity |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0006401 | biological_process | RNA catabolic process |
A | 0006935 | biological_process | chemotaxis |
A | 0019731 | biological_process | antibacterial humoral response |
A | 0035578 | cellular_component | azurophil granule lumen |
A | 0042742 | biological_process | defense response to bacterium |
A | 0043152 | biological_process | induction of bacterial agglutination |
A | 0045087 | biological_process | innate immune response |
A | 0050829 | biological_process | defense response to Gram-negative bacterium |
A | 0050830 | biological_process | defense response to Gram-positive bacterium |
A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
B | 0001530 | molecular_function | lipopolysaccharide binding |
B | 0002227 | biological_process | innate immune response in mucosa |
B | 0003676 | molecular_function | nucleic acid binding |
B | 0004519 | molecular_function | endonuclease activity |
B | 0004540 | molecular_function | RNA nuclease activity |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0006401 | biological_process | RNA catabolic process |
B | 0006935 | biological_process | chemotaxis |
B | 0019731 | biological_process | antibacterial humoral response |
B | 0035578 | cellular_component | azurophil granule lumen |
B | 0042742 | biological_process | defense response to bacterium |
B | 0043152 | biological_process | induction of bacterial agglutination |
B | 0045087 | biological_process | innate immune response |
B | 0050829 | biological_process | defense response to Gram-negative bacterium |
B | 0050830 | biological_process | defense response to Gram-positive bacterium |
B | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE FE B 300 |
Chain | Residue |
B | ARG34 |
B | CIT302 |
B | HOH2144 |
site_id | AC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE FE A 300 |
Chain | Residue |
A | CIT302 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CIT A 301 |
Chain | Residue |
A | PHE76 |
A | VAL78 |
A | TYR107 |
A | HOH2109 |
A | HOH2180 |
A | HOH2181 |
A | HOH2182 |
B | ARG121 |
A | THR46 |
A | ASN50 |
A | VAL54 |
A | SER74 |
A | ARG75 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE CIT B 301 |
Chain | Residue |
A | ARG61 |
A | ARG66 |
B | THR46 |
B | ASN50 |
B | VAL54 |
B | SER74 |
B | ARG75 |
B | PHE76 |
B | VAL78 |
B | TYR107 |
B | HOH2083 |
B | HOH2142 |
B | HOH2143 |
site_id | AC5 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE CIT A 302 |
Chain | Residue |
A | ARG34 |
A | LYS38 |
A | ASN39 |
A | GLN40 |
A | FE300 |
A | HOH2094 |
A | HOH2096 |
A | HOH2183 |
A | HOH2184 |
A | HOH2185 |
site_id | AC6 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE CIT B 302 |
Chain | Residue |
B | ARG34 |
B | ARG36 |
B | CYS37 |
B | LYS38 |
B | ASN39 |
B | GLN40 |
B | FE300 |
B | HOH2068 |
B | HOH2144 |
B | HOH2145 |
B | HOH2146 |
B | HOH2147 |
Functional Information from PROSITE/UniProt
site_id | PS00127 |
Number of Residues | 7 |
Details | RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKnqNTF |
Chain | Residue | Details |
A | CYS37-PHE43 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor |
Chain | Residue | Details |
A | HIS15 | |
B | HIS15 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor |
Chain | Residue | Details |
A | HIS128 | |
B | HIS128 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
A | LYS38 | |
B | LYS38 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: May be involved in LPS-binding |
Chain | Residue | Details |
A | TYR33 | |
B | TYR33 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | SITE: May be involved in LPS- and LTA-binding |
Chain | Residue | Details |
A | TRP35 | |
B | TRP35 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:18694936 |
Chain | Residue | Details |
A | TYR33 | |
B | TYR33 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN57 | |
A | ASN65 | |
A | ASN92 | |
B | ASN57 | |
B | ASN65 | |
B | ASN92 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4y |
Chain | Residue | Details |
A | LYS38 | |
A | HIS15 | |
A | HIS128 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a4y |
Chain | Residue | Details |
B | LYS38 | |
B | HIS15 | |
B | HIS128 |