1DXQ

CRYSTAL STRUCTURE OF MOUSE NAD[P]H-QUINONE OXIDOREDUCTASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000209	biological_process	protein polyubiquitination
A	0003955	molecular_function	NAD(P)H dehydrogenase (quinone) activity
A	0004784	molecular_function	superoxide dismutase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006743	biological_process	ubiquinone metabolic process
A	0006801	biological_process	superoxide metabolic process
A	0006979	biological_process	response to oxidative stress
A	0008753	molecular_function	NADPH dehydrogenase (quinone) activity
A	0009410	biological_process	response to xenobiotic stimulus
A	0016491	molecular_function	oxidoreductase activity
A	0019430	biological_process	removal of superoxide radicals
A	0030163	biological_process	protein catabolic process
A	0030425	cellular_component	dendrite
A	0032496	biological_process	response to lipopolysaccharide
A	0034599	biological_process	cellular response to oxidative stress
A	0042177	biological_process	negative regulation of protein catabolic process
A	0042360	biological_process	vitamin E metabolic process
A	0042373	biological_process	vitamin K metabolic process
A	0042802	molecular_function	identical protein binding
A	0043025	cellular_component	neuronal cell body
A	0043066	biological_process	negative regulation of apoptotic process
A	0043086	biological_process	negative regulation of catalytic activity
A	0043525	biological_process	positive regulation of neuron apoptotic process
A	0045087	biological_process	innate immune response
A	0045454	biological_process	cell redox homeostasis
A	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
A	0061771	biological_process	response to caloric restriction
A	0070301	biological_process	cellular response to hydrogen peroxide
A	0110076	biological_process	negative regulation of ferroptosis
A	1902690	biological_process	positive regulation of NAD metabolic process
A	1904844	biological_process	response to L-glutamine
B	0000209	biological_process	protein polyubiquitination
B	0003955	molecular_function	NAD(P)H dehydrogenase (quinone) activity
B	0004784	molecular_function	superoxide dismutase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006743	biological_process	ubiquinone metabolic process
B	0006801	biological_process	superoxide metabolic process
B	0006979	biological_process	response to oxidative stress
B	0008753	molecular_function	NADPH dehydrogenase (quinone) activity
B	0009410	biological_process	response to xenobiotic stimulus
B	0016491	molecular_function	oxidoreductase activity
B	0019430	biological_process	removal of superoxide radicals
B	0030163	biological_process	protein catabolic process
B	0030425	cellular_component	dendrite
B	0032496	biological_process	response to lipopolysaccharide
B	0034599	biological_process	cellular response to oxidative stress
B	0042177	biological_process	negative regulation of protein catabolic process
B	0042360	biological_process	vitamin E metabolic process
B	0042373	biological_process	vitamin K metabolic process
B	0042802	molecular_function	identical protein binding
B	0043025	cellular_component	neuronal cell body
B	0043066	biological_process	negative regulation of apoptotic process
B	0043086	biological_process	negative regulation of catalytic activity
B	0043525	biological_process	positive regulation of neuron apoptotic process
B	0045087	biological_process	innate immune response
B	0045454	biological_process	cell redox homeostasis
B	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
B	0061771	biological_process	response to caloric restriction
B	0070301	biological_process	cellular response to hydrogen peroxide
B	0110076	biological_process	negative regulation of ferroptosis
B	1902690	biological_process	positive regulation of NAD metabolic process
B	1904844	biological_process	response to L-glutamine
C	0000209	biological_process	protein polyubiquitination
C	0003955	molecular_function	NAD(P)H dehydrogenase (quinone) activity
C	0004784	molecular_function	superoxide dismutase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006743	biological_process	ubiquinone metabolic process
C	0006801	biological_process	superoxide metabolic process
C	0006979	biological_process	response to oxidative stress
C	0008753	molecular_function	NADPH dehydrogenase (quinone) activity
C	0009410	biological_process	response to xenobiotic stimulus
C	0016491	molecular_function	oxidoreductase activity
C	0019430	biological_process	removal of superoxide radicals
C	0030163	biological_process	protein catabolic process
C	0030425	cellular_component	dendrite
C	0032496	biological_process	response to lipopolysaccharide
C	0034599	biological_process	cellular response to oxidative stress
C	0042177	biological_process	negative regulation of protein catabolic process
C	0042360	biological_process	vitamin E metabolic process
C	0042373	biological_process	vitamin K metabolic process
C	0042802	molecular_function	identical protein binding
C	0043025	cellular_component	neuronal cell body
C	0043066	biological_process	negative regulation of apoptotic process
C	0043086	biological_process	negative regulation of catalytic activity
C	0043525	biological_process	positive regulation of neuron apoptotic process
C	0045087	biological_process	innate immune response
C	0045454	biological_process	cell redox homeostasis
C	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
C	0061771	biological_process	response to caloric restriction
C	0070301	biological_process	cellular response to hydrogen peroxide
C	0110076	biological_process	negative regulation of ferroptosis
C	1902690	biological_process	positive regulation of NAD metabolic process
C	1904844	biological_process	response to L-glutamine
D	0000209	biological_process	protein polyubiquitination
D	0003955	molecular_function	NAD(P)H dehydrogenase (quinone) activity
D	0004784	molecular_function	superoxide dismutase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006743	biological_process	ubiquinone metabolic process
D	0006801	biological_process	superoxide metabolic process
D	0006979	biological_process	response to oxidative stress
D	0008753	molecular_function	NADPH dehydrogenase (quinone) activity
D	0009410	biological_process	response to xenobiotic stimulus
D	0016491	molecular_function	oxidoreductase activity
D	0019430	biological_process	removal of superoxide radicals
D	0030163	biological_process	protein catabolic process
D	0030425	cellular_component	dendrite
D	0032496	biological_process	response to lipopolysaccharide
D	0034599	biological_process	cellular response to oxidative stress
D	0042177	biological_process	negative regulation of protein catabolic process
D	0042360	biological_process	vitamin E metabolic process
D	0042373	biological_process	vitamin K metabolic process
D	0042802	molecular_function	identical protein binding
D	0043025	cellular_component	neuronal cell body
D	0043066	biological_process	negative regulation of apoptotic process
D	0043086	biological_process	negative regulation of catalytic activity
D	0043525	biological_process	positive regulation of neuron apoptotic process
D	0045087	biological_process	innate immune response
D	0045454	biological_process	cell redox homeostasis
D	0050136	molecular_function	NADH dehydrogenase (quinone) (non-electrogenic) activity
D	0061771	biological_process	response to caloric restriction
D	0070301	biological_process	cellular response to hydrogen peroxide
D	0110076	biological_process	negative regulation of ferroptosis
D	1902690	biological_process	positive regulation of NAD metabolic process
D	1904844	biological_process	response to L-glutamine

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE FAD A 300

Chain	Residue
A	HIS11
A	TRP105
A	PHE106
A	THR147
A	THR148
A	GLY149
A	GLY150
A	TYR155
A	ARG200
A	MET201
C	GLN66
A	THR15
C	PRO68
C	GLU117
A	SER16
A	PHE17
A	ASN18
A	ALA20
A	PRO102
A	LEU103
A	GLN104

---

site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE FAD B 300

Chain	Residue
A	LYS240
B	HIS11
B	THR15
B	SER16
B	PHE17
B	ASN18
B	ALA20
B	PRO102
B	LEU103
B	GLN104
B	TRP105
B	PHE106
B	THR147
B	THR148
B	GLY149
B	GLY150
B	TYR155
B	ARG200
B	MET201
D	GLN66
D	PRO68
D	GLU117

---

site_id	AC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE FAD C 300

Chain	Residue
A	ASN64
A	GLN66
A	TYR67
A	PRO68
A	GLU117
C	HIS11
C	THR15
C	SER16
C	PHE17
C	ASN18
C	ALA20
C	PRO102
C	LEU103
C	GLN104
C	TRP105
C	PHE106
C	THR147
C	THR148
C	GLY149
C	GLY150
C	TYR155
C	ARG200
C	MET201

---

site_id	AC4
Number of Residues	20
Details	BINDING SITE FOR RESIDUE FAD D 300

Chain	Residue
B	GLN66
B	PRO68
B	GLU117
D	HIS11
D	THR15
D	SER16
D	PHE17
D	ASN18
D	ALA20
D	PRO102
D	LEU103
D	GLN104
D	TRP105
D	PHE106
D	THR147
D	THR148
D	GLY149
D	GLY150
D	TYR155
D	ARG200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	196
Details	Region: {"description":"Important for apoenzyme conformational stability","evidences":[{"source":"UniProtKB","id":"P15559","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10706635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"PubMed","id":"7527260","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P15559","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P15559","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1d4a

Chain	Residue	Details
A	TYR155
A	HIS161
A	GLY149

---

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1d4a

Chain	Residue	Details
B	TYR155
B	HIS161
B	GLY149

---

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1d4a

Chain	Residue	Details
C	TYR155
C	HIS161
C	GLY149

---

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1d4a

Chain	Residue	Details
D	TYR155
D	HIS161
D	GLY149

---