1DWX
MURINE INDUCIBLE NITRIC OXIDE SYNTHASE OXYGENASE DIMER N-hydroxyarginine and tetrahydrobiopterin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004517 | molecular_function | nitric-oxide synthase activity |
| A | 0006809 | biological_process | nitric oxide biosynthetic process |
| A | 0020037 | molecular_function | heme binding |
| B | 0004517 | molecular_function | nitric-oxide synthase activity |
| B | 0006809 | biological_process | nitric oxide biosynthetic process |
| B | 0020037 | molecular_function | heme binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 903 |
| Chain | Residue |
| A | LEU94 |
| A | LYS97 |
| A | GLN143 |
| A | ARG448 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE HEM A 901 |
| Chain | Residue |
| A | GLY365 |
| A | TRP366 |
| A | GLU371 |
| A | TRP457 |
| A | TYR485 |
| A | H4B902 |
| A | HAR906 |
| A | HOH2157 |
| A | HOH2158 |
| A | HOH2159 |
| A | TRP188 |
| A | CYS194 |
| A | SER236 |
| A | PHE363 |
| A | ASN364 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE H4B A 902 |
| Chain | Residue |
| A | SER112 |
| A | ARG375 |
| A | TRP455 |
| A | ILE456 |
| A | TRP457 |
| A | PHE470 |
| A | HIS471 |
| A | GLU473 |
| A | HEM901 |
| A | HOH2137 |
| A | HOH2157 |
| A | HOH2160 |
| A | HOH2161 |
| A | HOH2162 |
| A | HOH2163 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE HAR A 906 |
| Chain | Residue |
| A | GLN257 |
| A | TYR341 |
| A | PRO344 |
| A | VAL346 |
| A | GLY365 |
| A | TRP366 |
| A | TYR367 |
| A | GLU371 |
| A | ASP376 |
| A | HEM901 |
| A | HOH2113 |
| A | HOH2164 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE HEM B 901 |
| Chain | Residue |
| B | TRP188 |
| B | ARG193 |
| B | CYS194 |
| B | SER236 |
| B | PHE363 |
| B | ASN364 |
| B | GLY365 |
| B | TRP366 |
| B | GLU371 |
| B | TRP457 |
| B | TYR483 |
| B | TYR485 |
| B | H4B902 |
| B | HAR906 |
| B | HOH2183 |
| B | HOH2184 |
| B | HOH2185 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE H4B B 902 |
| Chain | Residue |
| B | SER112 |
| B | ARG375 |
| B | TRP455 |
| B | ILE456 |
| B | TRP457 |
| B | PHE470 |
| B | HIS471 |
| B | GLN472 |
| B | GLU473 |
| B | HEM901 |
| B | HOH2169 |
| B | HOH2170 |
| B | HOH2174 |
| B | HOH2185 |
| B | HOH2187 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE HAR B 906 |
| Chain | Residue |
| B | GLN257 |
| B | TYR341 |
| B | PRO344 |
| B | GLY365 |
| B | TRP366 |
| B | TYR367 |
| B | GLU371 |
| B | ASP376 |
| B | HEM901 |
| B | HOH2133 |
| B | HOH2188 |
Functional Information from PROSITE/UniProt
| site_id | PS60001 |
| Number of Residues | 8 |
| Details | NOS Nitric oxide synthase (NOS) signature. RCIGRIqW |
| Chain | Residue | Details |
| A | ARG193-TRP200 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1N2N |
| Chain | Residue | Details |
| A | CYS104 | |
| A | CYS109 | |
| B | CYS104 | |
| B | CYS109 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD |
| Chain | Residue | Details |
| A | SER112 | |
| B | SER112 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9334294, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWV, ECO:0007744|PDB:1DWW, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOC, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1NOS, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:2NOS, ECO:0007744|PDB:3NOD |
| Chain | Residue | Details |
| A | CYS194 | |
| B | CYS194 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P29474 |
| Chain | Residue | Details |
| A | GLN257 | |
| A | TRP366 | |
| A | TYR367 | |
| A | GLU371 | |
| B | GLN257 | |
| B | TRP366 | |
| B | TYR367 | |
| B | GLU371 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:3NOD |
| Chain | Residue | Details |
| A | ARG375 | |
| B | ARG375 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N |
| Chain | Residue | Details |
| A | ILE456 | |
| B | ILE456 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1M9T, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD |
| Chain | Residue | Details |
| A | TRP457 | |
| B | TRP457 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:11669619, ECO:0000269|PubMed:12437348, ECO:0000269|PubMed:12464241, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1JWJ, ECO:0007744|PDB:1JWK, ECO:0007744|PDB:1M8D, ECO:0007744|PDB:1M8E, ECO:0007744|PDB:1M8H, ECO:0007744|PDB:1M8I, ECO:0007744|PDB:1N2N, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD |
| Chain | Residue | Details |
| A | PHE470 | |
| B | PHE470 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10562539, ECO:0000269|PubMed:10769116, ECO:0000269|PubMed:9516116, ECO:0007744|PDB:1DF1, ECO:0007744|PDB:1DWX, ECO:0007744|PDB:1NOD, ECO:0007744|PDB:1QOM, ECO:0007744|PDB:2NOD, ECO:0007744|PDB:3NOD |
| Chain | Residue | Details |
| A | TYR485 | |
| B | TYR485 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| A | TRP366 | |
| A | ARG197 | |
| A | CYS194 | |
| A | GLU371 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 3nos |
| Chain | Residue | Details |
| B | TRP366 | |
| B | ARG197 | |
| B | CYS194 | |
| B | GLU371 |
