1DSZ

STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1121

Chain	Residue
A	CYS1135
A	CYS1138
A	CYS1152
A	CYS1155

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1122

Chain	Residue
A	CYS1171
A	CYS1177
A	CYS1187
A	CYS1190

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1221

Chain	Residue
B	CYS1238
B	CYS1252
B	CYS1255
B	CYS1235

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1222

Chain	Residue
B	CYS1271
B	CYS1277
B	CYS1287
B	CYS1290

---

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CfvCq.Dkssgy.HYgvsaCegCkgFFrR

Chain	Residue	Details
A	CYS1135-ARG1161
B	CYS1235-ARG1261

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	65
Details	DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
B	CYS1235-MET1300

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site_id	SWS_FT_FI2
Number of Residues	44
Details	ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407

Chain	Residue	Details
B	CYS1235-CYS1255
B	CYS1271-CYS1295

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4

Chain	Residue	Details
B	CYS1235
B	CYS1238
B	CYS1252
B	CYS1255
B	CYS1271
B	CYS1277
B	CYS1287
B	CYS1290

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER1229

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by EP300 => ECO:0000269|PubMed:17761950

Chain	Residue	Details
B	LYS1245

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