1DSY

C2 DOMAIN FROM PROTEIN KINASE C (ALPHA) COMPLEXED WITH CA2+ AND PHOSPHATIDYLSERINE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 501

Chain	Residue
A	MET186
A	ASP187
A	ASP246
A	ASP248
A	ASP254

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	ASP248
A	PSF401
A	ASP187
A	ASP193
A	ASP246
A	TRP247

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 601

Chain	Residue
A	TYR195
A	LYS197
A	LYS209
A	LYS211
A	ASN253
A	HOH316

---

site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PSF A 401

Chain	Residue
A	ASP187
A	PRO188
A	ASN189
A	ASP193
A	ASP203
A	GLU207
A	SER208
A	ARG216
A	ARG238
A	TRP247
A	ASP248
A	ARG249
A	THR250
A	THR251
A	HOH335
A	CA502

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	117
Details	Domain: {"description":"C2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00041","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562545","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10562545","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19346474","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19346474","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---