1DSY

C2 DOMAIN FROM PROTEIN KINASE C (ALPHA) COMPLEXED WITH CA2+ AND PHOSPHATIDYLSERINE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 501

Chain	Residue
A	MET186
A	ASP187
A	ASP246
A	ASP248
A	ASP254

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	ASP248
A	PSF401
A	ASP187
A	ASP193
A	ASP246
A	TRP247

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 A 601

Chain	Residue
A	TYR195
A	LYS197
A	LYS209
A	LYS211
A	ASN253
A	HOH316

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site_id	AC4
Number of Residues	16
Details	BINDING SITE FOR RESIDUE PSF A 401

Chain	Residue
A	ASP187
A	PRO188
A	ASN189
A	ASP193
A	ASP203
A	GLU207
A	SER208
A	ARG216
A	ARG238
A	TRP247
A	ASP248
A	ARG249
A	THR250
A	THR251
A	HOH335
A	CA502

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:10562545

Chain	Residue	Details
A	MET186

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site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:10562545, ECO:0000269|PubMed:19346474

Chain	Residue	Details
A	ASP187
A	ASP193
A	ASP246
A	TRP247
A	ASP248
A	ARG252
A	ASP254

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:19346474

Chain	Residue	Details
A	TYR195
A	TRP245

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903

Chain	Residue	Details
A	SER226

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