1DRV
ESCHERICHIA COLI DHPR/ACNADH COMPLEX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008839 | molecular_function | 4-hydroxy-tetrahydrodipicolinate reductase |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016726 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE A3D A 301 |
| Chain | Residue |
| A | GLY12 |
| A | GLY15 |
| A | ARG16 |
| A | MET17 |
| A | GLU38 |
| A | ARG39 |
| A | PHE79 |
| A | THR80 |
| A | ARG81 |
| A | GLY84 |
| A | GLY102 |
| A | THR104 |
| A | ALA126 |
| A | ALA127 |
| A | ASN128 |
| A | PHE129 |
| A | ARG240 |
| A | PHE243 |
| A | HOH402 |
| A | HOH439 |
| site_id | BIN |
| Number of Residues | 15 |
| Details | DINUCLEOTIDE BINDING SITE |
| Chain | Residue |
| A | GLY12 |
| A | GLY102 |
| A | THR104 |
| A | ALA126 |
| A | ALA127 |
| A | PHE129 |
| A | ARG240 |
| A | GLY15 |
| A | ARG16 |
| A | MET17 |
| A | GLU38 |
| A | ARG39 |
| A | THR80 |
| A | ARG81 |
| A | GLY84 |
Functional Information from PROSITE/UniProt
| site_id | PS01298 |
| Number of Residues | 18 |
| Details | DAPB Dihydrodipicolinate reductase signature. EIiEaHhrhKvDapSGTA |
| Chain | Residue | Details |
| A | GLU154-ALA171 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7893645","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DIH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8873595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9398235","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ARZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1DRU","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"9398235","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ARZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1arz |
| Chain | Residue | Details |
| A | HIS159 | |
| A | LYS163 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 402 |
| Chain | Residue | Details |
| A | HIS159 | activator, proton shuttle (general acid/base) |
| A | LYS163 | activator, electrostatic stabiliser, proton shuttle (general acid/base) |
