Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1DP0

E. COLI BETA-GALACTOSIDASE AT 1.7 ANGSTROM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004565	molecular_function	beta-galactosidase activity
A	0005975	biological_process	carbohydrate metabolic process
A	0005990	biological_process	lactose catabolic process
A	0009341	cellular_component	beta-galactosidase complex
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0030246	molecular_function	carbohydrate binding
A	0031420	molecular_function	alkali metal ion binding
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0004565	molecular_function	beta-galactosidase activity
B	0005975	biological_process	carbohydrate metabolic process
B	0005990	biological_process	lactose catabolic process
B	0009341	cellular_component	beta-galactosidase complex
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0030246	molecular_function	carbohydrate binding
B	0031420	molecular_function	alkali metal ion binding
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
C	0004565	molecular_function	beta-galactosidase activity
C	0005975	biological_process	carbohydrate metabolic process
C	0005990	biological_process	lactose catabolic process
C	0009341	cellular_component	beta-galactosidase complex
C	0016787	molecular_function	hydrolase activity
C	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
C	0030246	molecular_function	carbohydrate binding
C	0031420	molecular_function	alkali metal ion binding
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
D	0004565	molecular_function	beta-galactosidase activity
D	0005975	biological_process	carbohydrate metabolic process
D	0005990	biological_process	lactose catabolic process
D	0009341	cellular_component	beta-galactosidase complex
D	0016787	molecular_function	hydrolase activity
D	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
D	0030246	molecular_function	carbohydrate binding
D	0031420	molecular_function	alkali metal ion binding
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 3001

Chain	Residue
A	GLU416
A	HIS418
A	GLU461
A	HOH8616
A	HOH8680
A	HOH8756

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 3002

Chain	Residue
A	GLN163
A	ASP193
A	ASP15
A	ASN18
A	VAL21

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 3003

Chain	Residue
A	GLN718
A	HOH8865
A	HOH8980
A	HOH9044
A	HOH9237
A	HOH9307

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 3005

Chain	Residue
A	DMS8406
A	HOH9262
A	HOH9482
A	HOH9483
A	HOH9582
D	HOH9743

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 3101

Chain	Residue
A	TYR100
A	ASP201
A	PHE601
A	ASN604
A	HOH8770
A	HOH8875

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 3102

Chain	Residue
A	PHE556
A	TYR559
A	PRO560
A	LEU562
A	HOH9004
A	HOH9240

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 3103

Chain	Residue
A	PHE931
A	PRO932
A	LEU967
A	THR970
A	HOH8806
A	HOH9348

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 3104

Chain	Residue
A	SER647
A	GLU650
A	LEU670
A	DMS8425
A	HOH9361
A	HOH9556

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 3105

Chain	Residue
A	ASN597
A	HOH8822
A	HOH9048
A	HOH9093
A	HOH9216
A	HOH9704

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 3001

Chain	Residue
B	GLU416
B	HIS418
B	GLU461
B	HOH8634
B	HOH8698
B	HOH8774

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 3002

Chain	Residue
B	ASP15
B	ASN18
B	VAL21
B	GLN163
B	ASP193

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 3003

Chain	Residue
B	GLN718
B	HOH8884
B	HOH8998
B	HOH9060
B	HOH9251
B	HOH9321

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 3101

Chain	Residue
B	TYR100
B	ASP201
B	PHE601
B	ASN604
B	HOH8788
B	HOH8894

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 3102

Chain	Residue
B	PHE556
B	TYR559
B	PRO560
B	LEU562
B	HOH9022
B	HOH9254

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 3103

Chain	Residue
B	PHE931
B	PRO932
B	LEU967
B	THR970
B	HOH8824

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 3104

Chain	Residue
B	SER647
B	GLU650
B	LEU670
B	DMS8425
B	HOH9375
B	HOH9545

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 3105

Chain	Residue
B	ASN597
B	HOH8841
B	HOH9064
B	HOH9109
B	HOH9230

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 3001

Chain	Residue
C	HIS418
C	GLU461
C	HOH8645
C	HOH8709
C	HOH8786
C	GLU416

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 3002

Chain	Residue
C	ASP15
C	ASN18
C	VAL21
C	GLN163
C	ASP193

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 3003

Chain	Residue
C	GLN718
C	HOH8896
C	HOH9010
C	HOH9073
C	HOH9265
C	HOH9334

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 3004

Chain	Residue
B	HOH9592
B	HOH9663
C	HOH9592
C	HOH9594
C	HOH9609
C	HOH9655

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 3006

Chain	Residue
A	HOH9669
A	HOH9670
B	HOH9665
C	HOH9550
C	HOH9596
C	HOH9631

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C 3101

Chain	Residue
C	TYR100
C	ASP201
C	PHE601
C	ASN604
C	HOH8800
C	HOH8906

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C 3102

Chain	Residue
C	PHE556
C	TYR559
C	PRO560
C	LEU562
C	HOH9034
C	HOH9268

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA C 3103

Chain	Residue
C	PHE931
C	PRO932
C	LEU967
C	THR970
C	HOH8836
C	HOH9374

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA C 3104

Chain	Residue
C	SER647
C	GLU650
C	LEU670
C	DMS8425
C	HOH9389

site_id	CC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA C 3105

Chain	Residue
C	ASN597
C	HOH8853
C	HOH9077
C	HOH9122
C	HOH9244

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 3001

Chain	Residue
D	GLU416
D	HIS418
D	GLU461
D	HOH8759
D	HOH8823
D	HOH8900

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 3002

Chain	Residue
D	ASP15
D	ASN18
D	VAL21
D	GLN163
D	ASP193

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 3003

Chain	Residue
D	GLN718
D	HOH9010
D	HOH9125
D	HOH9189
D	HOH9380
D	HOH9450

site_id	DC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 3005

Chain	Residue
A	HOH9671
D	HOH9405
D	HOH9603
D	HOH9609
D	HOH9610
D	HOH9711

site_id	DC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 3101

Chain	Residue
D	TYR100
D	ASP201
D	PHE601
D	ASN604
D	HOH8914
D	HOH9020

site_id	DC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 3102

Chain	Residue
D	PHE556
D	TYR559
D	PRO560
D	LEU562
D	HOH9150
D	HOH9383

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 3103

Chain	Residue
D	PHE931
D	PRO932
D	LEU967
D	THR970
D	HOH8949
D	HOH9491

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA D 3104

Chain	Residue
D	SER647
D	GLU650
D	LEU670
D	DMS8425

site_id	DC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA D 3105

Chain	Residue
D	ASN597
D	GLU797
D	HOH8967
D	HOH9193
D	HOH9238
D	HOH9360

site_id	EC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 8401

Chain	Residue
A	THR229
A	VAL330
A	GLY331
A	ASN449
A	PRO451
A	HOH8613

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 8402

Chain	Residue
A	ARG557
A	HIS622
A	GLN625
A	GLN628
A	HOH8804

site_id	EC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 8403

Chain	Residue
A	LYS380
A	ASN383
A	PHE626
A	TYR642
A	TRP708
A	HOH8813

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 8404

Chain	Residue
A	PRO32
A	PHE33
A	TRP36
A	ALA327
A	HOH9017
A	HOH9251

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 8405

Chain	Residue
A	THR271
A	LEU291
A	ARG292
A	HOH9310

site_id	EC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 8406

Chain	Residue
A	GLU314
A	HIS316
A	GLY320
A	MG3005
D	DMS8703

site_id	EC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 8407

Chain	Residue
A	GLU508
A	PRO1001
A	VAL1003
A	HOH8639
A	HOH9091

site_id	EC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 8408

Chain	Residue
A	LEU54
A	ASN55
A	PHE127
A	HOH9335
A	HOH9349

site_id	EC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 8409

Chain	Residue
A	VAL335
A	PRO480
A	HOH8808
A	HOH8811
A	HOH9118

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 8410

Chain	Residue
A	PRO106
A	PRO115
A	HOH8967
A	HOH9242

site_id	FC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 8411

Chain	Residue
A	ILE576
A	SER586
A	ARG973
A	HOH8704

site_id	FC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 8412

Chain	Residue
A	GLY276
A	GLU277
A	VAL289
A	THR290
A	ARG292
A	HOH9205

site_id	FC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 8413

Chain	Residue
A	GLY593
A	ASP594
A	THR595
A	HOH8950

site_id	FC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 8414

Chain	Residue
A	VAL84
A	VAL85
A	HIS93

site_id	FC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 8415

Chain	Residue
A	LYS621
A	TRP717
A	HOH8936
A	HOH9627

site_id	FC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 8416

Chain	Residue
A	ARG251
A	ASP252
D	ARG251

site_id	FC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 8417

Chain	Residue
A	PHE231
A	ASN232
A	ASP233
A	PHE235
A	GLU334
A	HOH9234

site_id	FC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 8419

Chain	Residue
A	PRO106
A	PRO596
A	HOH9074

site_id	GC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 8420

Chain	Residue
A	ASP428
A	PRO430
D	VAL478
D	HOH9261
D	HOH9556

site_id	GC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 8421

Chain	Residue
A	HIS93
A	GLY94
A	TYR95
A	HOH9129
A	HOH9238

site_id	GC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 8423

Chain	Residue
A	TYR926
A	TYR962
A	ARG973
A	LEU976
A	HOH9163

site_id	GC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS A 8425

Chain	Residue
A	SER647
A	ASP648
A	ASN649
A	GLU650
A	ASN704
A	NA3104
A	HOH9441
C	LYS1023

site_id	GC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS A 8427

Chain	Residue
A	TRP695
A	GLN719
A	TRP720
A	ARG721
A	HOH8812
A	HOH9005
A	HOH9027
A	HOH9044

site_id	GC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 8501

Chain	Residue
A	ASP45
A	ARG46
A	PRO47
A	HOH9105
A	HOH9403

site_id	GC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS A 8502

Chain	Residue
A	GLU57
A	TRP58
A	ARG59
A	LEU125
A	THR126
A	HOH9132
A	HOH9384
B	GLU819

site_id	GC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS A 8503

Chain	Residue
A	PHE629
A	ARG630
A	GLN718
A	TRP720
A	HOH8835

site_id	GC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS A 8504

Chain	Residue
A	SER132
A	TRP133
A	GLU136
A	HIS216

site_id	HC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS A 8602

Chain	Residue
A	GLN266
A	VAL267
A	ALA268

site_id	HC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS B 8401

Chain	Residue
B	THR229
B	VAL330
B	GLY331
B	ASN449
B	PRO451
B	HOH8631

site_id	HC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS B 8402

Chain	Residue
B	ARG557
B	HIS622
B	GLN625
B	GLN628
B	HOH8822

site_id	HC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS B 8403

Chain	Residue
B	LYS380
B	ASN383
B	PHE626
B	TYR642
B	TRP708
B	HOH8831

site_id	HC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS B 8404

Chain	Residue
B	PRO32
B	PHE33
B	ALA34
B	TRP36
B	ASP45
B	ALA327
B	HOH9034
B	HOH9264

site_id	HC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS B 8405

Chain	Residue
B	THR271
B	LEU291
B	ARG292
B	HOH9324
B	HOH9461

site_id	HC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS B 8406

Chain	Residue
B	GLU314
B	HIS316
B	GLY320
B	HOH8611

site_id	HC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS B 8407

Chain	Residue
B	ARG505
B	GLU508
B	PRO1001
B	HOH8657
B	HOH8862
B	HOH9107

site_id	HC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS B 8408

Chain	Residue
B	LEU54
B	ASN55
B	HOH9361

site_id	IC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS B 8409

Chain	Residue
B	GLU334
B	VAL335
B	PRO480
B	HOH8826
B	HOH8829
B	HOH9134

site_id	IC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS B 8410

Chain	Residue
B	PRO106
B	PRO115
B	TRP191
B	HOH8882
B	HOH8985
B	HOH9256

site_id	IC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS B 8411

Chain	Residue
B	SER586
B	ARG973
B	HOH8722

site_id	IC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS B 8412

Chain	Residue
B	GLY275
B	THR290
B	ARG292
B	HOH9516

site_id	IC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS B 8413

Chain	Residue
B	GLY593
B	ASP594
B	THR595
B	HOH8967
B	HOH9377

site_id	IC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS B 8414

Chain	Residue
B	VAL84
B	VAL85
B	HIS93

site_id	IC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS B 8415

Chain	Residue
B	LYS621
B	TRP717
B	HOH8953

site_id	IC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS B 8416

Chain	Residue
B	ARG251
B	ASP252

site_id	IC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS B 8417

Chain	Residue
B	PHE231
B	ASN232
B	ASP233
B	PHE235
B	GLU334
B	HOH9248

site_id	JC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE DMS B 8420

Chain	Residue
B	ASP428

site_id	JC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS B 8421

Chain	Residue
B	HIS93
B	TYR95
B	HOH9252

site_id	JC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS B 8423

Chain	Residue
B	TYR926
B	TYR962
B	ARG973

site_id	JC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS B 8425

Chain	Residue
B	SER647
B	ASP648
B	ASN649
B	GLU650
B	ASN704
B	NA3104

site_id	JC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS B 8427

Chain	Residue
B	GLN719
B	ARG721
B	HOH8900
B	HOH9060
B	HOH9160

site_id	JC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS B 8502

Chain	Residue
B	GLU57
B	TRP58
B	LEU125
B	THR126
B	HOH9148

site_id	JC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS B 8504

Chain	Residue
B	ARG37
B	TRP133
B	HIS216
C	HOH9658

site_id	JC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS B 8506

Chain	Residue
B	ASN102
B	ASP598
B	PHE601
B	HOH9523

site_id	JC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS B 8508

Chain	Residue
B	SER923
B	TYR926
B	ARG961
B	TYR962
B	HOH8731

site_id	KC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS B 8601

Chain	Residue
B	VAL267
B	ASN294
B	VAL295
B	GLU296
B	HOH9192

site_id	KC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS C 8401

Chain	Residue
C	THR229
C	VAL330
C	GLY331
C	ASN449
C	PRO451
C	ARG482
C	HOH8642

site_id	KC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS C 8402

Chain	Residue
C	ARG557
C	HIS622
C	GLN628
C	HOH8834

site_id	KC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS C 8403

Chain	Residue
C	LYS380
C	ASN383
C	PHE626
C	TYR642
C	TRP708
C	HOH8843

site_id	KC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS C 8404

Chain	Residue
C	PRO32
C	PHE33
C	TRP36
C	ASP45
C	ALA327
C	HOH9046
C	HOH9279

site_id	KC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS C 8405

Chain	Residue
C	THR271
C	LEU291
C	ARG292
C	HOH9337

site_id	KC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS C 8407

Chain	Residue
C	GLU508
C	PRO1001
C	VAL1003
C	HOH8668
C	HOH9120
C	HOH9628

site_id	KC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS C 8408

Chain	Residue
C	LEU54
C	ASN55
C	HOH9375

site_id	KC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS C 8409

Chain	Residue
C	GLU334
C	VAL335
C	PRO480
C	HOH8838
C	HOH8841
C	HOH9147

site_id	LC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS C 8410

Chain	Residue
C	PRO106
C	PRO115
C	TRP191
C	HOH8998

site_id	LC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS C 8411

Chain	Residue
C	ILE576
C	PRO584
C	SER586
C	ARG973
C	HOH8733

site_id	LC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS C 8412

Chain	Residue
C	GLY275
C	VAL289
C	THR290
C	ARG292
C	HOH9534

site_id	LC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS C 8413

Chain	Residue
C	GLY593
C	ASP594
C	THR595
C	HOH8981
C	HOH9391

site_id	LC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS C 8414

Chain	Residue
C	VAL84
C	VAL85
C	HIS93

site_id	LC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS C 8415

Chain	Residue
C	LYS621
C	TRP717
C	HOH8967

site_id	LC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS C 8416

Chain	Residue
C	LEU250
C	ARG251
C	ASP252

site_id	LC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS C 8417

Chain	Residue
C	PHE231
C	ASN232
C	ASP233
C	PHE235
C	GLU334
C	HOH9262

site_id	LC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS C 8419

Chain	Residue
C	PRO106
C	THR108
C	HOH8970
C	HOH9103
C	HOH9441

site_id	MC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS C 8420

Chain	Residue
B	HOH9426
C	ASP428
C	PRO430

site_id	MC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE DMS C 8421

Chain	Residue
C	HIS93
C	HOH9266

site_id	MC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS C 8423

Chain	Residue
C	TYR926
C	TYR962
C	ARG973

site_id	MC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS C 8425

Chain	Residue
C	SER647
C	ASP648
C	ASN649
C	GLU650
C	PRO703
C	ASN704
C	NA3104

site_id	MC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS C 8427

Chain	Residue
C	GLN719
C	ARG721
C	HOH8842
C	HOH8912
C	HOH9073

site_id	MC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS C 8501

Chain	Residue
C	ASP45
C	ARG46
C	PRO47
C	HOH9134
C	HOH9436

site_id	MC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS C 8503

Chain	Residue
C	PHE629
C	GLN718
C	TRP720
C	HOH8866

site_id	MC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS C 8504

Chain	Residue
C	ARG37
C	SER132
C	TRP133
C	HIS216

site_id	MC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS C 8506

Chain	Residue
C	ASN102
C	ASP598
C	PHE601
C	HOH9491
C	HOH9543

site_id	NC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS C 8601

Chain	Residue
C	VAL267
C	ASN294
C	VAL295
C	GLU296
C	HOH9206

site_id	NC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS C 8602

Chain	Residue
C	GLN266
C	VAL267
C	ALA268
D	LEU740
D	THR742

site_id	NC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS D 8401

Chain	Residue
D	THR229
D	VAL330
D	GLY331
D	ASN449
D	PRO451
D	ARG482
D	HOH8756

site_id	NC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS D 8402

Chain	Residue
D	ARG557
D	HIS622
D	GLN623
D	GLN625
D	GLN628
D	HOH8947

site_id	NC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS D 8403

Chain	Residue
D	LYS380
D	ASN383
D	PHE626
D	TYR642
D	TRP708
D	HOH8956

site_id	NC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS D 8404

Chain	Residue
D	PRO32
D	PHE33
D	ALA34
D	TRP36
D	ALA327
D	HOH9175

site_id	NC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS D 8405

Chain	Residue
D	THR271
D	LEU291
D	ARG292
D	HOH9453

site_id	NC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS D 8406

Chain	Residue
A	GLU136
D	GLU314
D	HIS316
D	GLY320
D	DMS8701
D	HOH9756

site_id	NC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS D 8407

Chain	Residue
D	GLU508
D	PRO1001
D	HOH8782
D	HOH9127
D	HOH9236

site_id	OC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS D 8408

Chain	Residue
D	LEU54
D	ASN55
D	GLY56
D	GLU57
D	HOH9492

site_id	OC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS D 8409

Chain	Residue
D	GLU334
D	VAL335
D	PRO480
D	HOH8951
D	HOH8954
D	HOH9262

site_id	OC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS D 8410

Chain	Residue
D	PRO106
D	PRO115
D	HOH9112
D	HOH9385

site_id	OC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS D 8411

Chain	Residue
D	ILE576
D	PRO584
D	SER586
D	ARG973
D	HOH8847

site_id	OC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS D 8412

Chain	Residue
D	GLY275
D	GLY276
D	GLU277
D	THR290
D	ARG292

site_id	OC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS D 8413

Chain	Residue
D	GLY593
D	ASP594
D	THR595
D	HOH9094
D	HOH9503

site_id	OC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS D 8414

Chain	Residue
D	VAL84
D	VAL85
D	HIS93

site_id	OC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS D 8415

Chain	Residue
D	LYS621
D	TRP717
D	HOH9080

site_id	OC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS D 8416

Chain	Residue
D	LEU250
D	ARG251
D	ASP252

site_id	PC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS D 8417

Chain	Residue
D	PHE231
D	ASN232
D	ASP233
D	PHE235
D	GLU334
D	ARG336
D	HOH9377

site_id	PC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS D 8419

Chain	Residue
D	TYR105
D	PRO106
D	ILE107
D	PRO596
D	HOH9219
D	HOH9533

site_id	PC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS D 8421

Chain	Residue
D	HIS93
D	GLY94
D	TYR95
D	HOH9381

site_id	PC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DMS D 8423

Chain	Residue
D	TYR926
D	TYR962
D	ARG973

site_id	PC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS D 8425

Chain	Residue
B	LYS1023
D	SER647
D	ASP648
D	ASN649
D	GLU650
D	PRO703
D	ASN704
D	NA3104

site_id	PC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS D 8427

Chain	Residue
D	TRP695
D	GLN719
D	TRP720
D	ARG721
D	HOH8955
D	HOH9026
D	HOH9189

site_id	PC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS D 8501

Chain	Residue
D	TRP36
D	ASP45
D	PRO47
D	HOH9250
D	HOH9544

site_id	PC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS D 8503

Chain	Residue
D	PHE629
D	ARG630
D	GLN718
D	TRP720
D	HOH8980

site_id	PC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS D 8506

Chain	Residue
D	ASN102
D	ASP598
D	PHE601
D	VAL795
D	HOH9400

site_id	QC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DMS D 8508

Chain	Residue
D	TYR926
D	ARG961
D	TYR962
D	HOH8856

site_id	QC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMS D 8701

Chain	Residue
A	GLU136
A	PRO218
A	ILE323
A	HOH9411
A	HOH9414
D	GLY320
D	LEU322
D	DMS8406

site_id	QC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS D 8703

Chain	Residue
A	DMS8406
D	GLN49
D	ASP130
D	SER132
D	TRP133
D	HOH9766

site_id	QC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DMS D 8705

Chain	Residue
D	TRP133
D	LEU134
D	GLN135
D	GLU136
D	SER174

Functional Information from PROSITE/UniProt

site_id	PS00608
Number of Residues	15
Details	GLYCOSYL_HYDROL_F2_2 Glycosyl hydrolases family 2 acid/base catalyst. DRNHPSVIIWSlg.NE

Chain	Residue	Details
A	ASP447-GLU461

site_id	PS00719
Number of Residues	26
Details	GLYCOSYL_HYDROL_F2_1 Glycosyl hydrolases family 2 signature 1. NaVRCSHYPnhplWYtlcDryGLYVV

Chain	Residue	Details
A	ASN385-VAL410

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"6420154","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"1350782","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11045615","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	8
Details	Site: {"description":"Transition state stabilizer"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Site: {"description":"Important for ensuring that an appropriate proportion of lactose is converted to allolactose"}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1bgl

Chain	Residue	Details
A	GLU461
A	GLU537

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1bgl

Chain	Residue	Details
B	GLU461
B	GLU537

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1bgl

Chain	Residue	Details
C	GLU461
C	GLU537

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1bgl

Chain	Residue	Details
D	GLU461
D	GLU537

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1bgl

Chain	Residue	Details
A	TYR503
A	GLU461
A	GLU537

site_id	CSA6
Number of Residues	3
Details	Annotated By Reference To The Literature 1bgl

Chain	Residue	Details
B	TYR503
B	GLU461
B	GLU537

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1bgl

Chain	Residue	Details
C	TYR503
C	GLU461
C	GLU537

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1bgl

Chain	Residue	Details
D	TYR503
D	GLU461
D	GLU537

site_id	MCSA1
Number of Residues	10
Details	M-CSA 422

Chain	Residue	Details
A	ASP201
A	ASN604
A	HIS357
A	HIS391
A	GLU416
A	HIS418
A	GLU461
A	GLU537
A	ASN597
A	PHE601

site_id	MCSA2
Number of Residues	10
Details	M-CSA 422

Chain	Residue	Details
B	ASP201
B	ASN604
B	HIS357
B	HIS391
B	GLU416
B	HIS418
B	GLU461
B	GLU537
B	ASN597
B	PHE601

site_id	MCSA3
Number of Residues	10
Details	M-CSA 422

Chain	Residue	Details
C	ASP201
C	ASN604
C	HIS357
C	HIS391
C	GLU416
C	HIS418
C	GLU461
C	GLU537
C	ASN597
C	PHE601

site_id	MCSA4
Number of Residues	10
Details	M-CSA 422

Chain	Residue	Details
D	ASP201
D	ASN604
D	HIS357
D	HIS391
D	GLU416
D	HIS418
D	GLU461
D	GLU537
D	ASN597
D	PHE601

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)