Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1DLA

NOVEL NADPH-BINDING DOMAIN REVEALED BY THE CRYSTAL STRUCTURE OF ALDOSE REDUCTASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
A	0004032	molecular_function	aldose reductase (NADPH) activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006060	biological_process	D-sorbitol metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0032866	molecular_function	D-xylose reductase (NADPH) activity
A	0032867	molecular_function	L-arabinose reductase (NADPH) activity
A	0036130	molecular_function	prostaglandin H2 endoperoxidase reductase activity
A	0042572	biological_process	retinol metabolic process
A	0047655	molecular_function	allyl-alcohol dehydrogenase activity
A	0047681	molecular_function	aryl-alcohol dehydrogenase (NADP+) activity
A	0047939	molecular_function	L-glucuronate reductase activity
A	0047956	molecular_function	glycerol dehydrogenase (NADP+) activity
A	0052650	molecular_function	all-trans-retinol dehydrogenase (NADP+) activity
B	0001523	biological_process	retinoid metabolic process
B	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
B	0004032	molecular_function	aldose reductase (NADPH) activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006060	biological_process	D-sorbitol metabolic process
B	0006693	biological_process	prostaglandin metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0032866	molecular_function	D-xylose reductase (NADPH) activity
B	0032867	molecular_function	L-arabinose reductase (NADPH) activity
B	0036130	molecular_function	prostaglandin H2 endoperoxidase reductase activity
B	0042572	biological_process	retinol metabolic process
B	0047655	molecular_function	allyl-alcohol dehydrogenase activity
B	0047681	molecular_function	aryl-alcohol dehydrogenase (NADP+) activity
B	0047939	molecular_function	L-glucuronate reductase activity
B	0047956	molecular_function	glycerol dehydrogenase (NADP+) activity
B	0052650	molecular_function	all-trans-retinol dehydrogenase (NADP+) activity
C	0001523	biological_process	retinoid metabolic process
C	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
C	0004032	molecular_function	aldose reductase (NADPH) activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006060	biological_process	D-sorbitol metabolic process
C	0006693	biological_process	prostaglandin metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0032866	molecular_function	D-xylose reductase (NADPH) activity
C	0032867	molecular_function	L-arabinose reductase (NADPH) activity
C	0036130	molecular_function	prostaglandin H2 endoperoxidase reductase activity
C	0042572	biological_process	retinol metabolic process
C	0047655	molecular_function	allyl-alcohol dehydrogenase activity
C	0047681	molecular_function	aryl-alcohol dehydrogenase (NADP+) activity
C	0047939	molecular_function	L-glucuronate reductase activity
C	0047956	molecular_function	glycerol dehydrogenase (NADP+) activity
C	0052650	molecular_function	all-trans-retinol dehydrogenase (NADP+) activity
D	0001523	biological_process	retinoid metabolic process
D	0001758	molecular_function	retinal dehydrogenase (NAD+) activity
D	0004032	molecular_function	aldose reductase (NADPH) activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006060	biological_process	D-sorbitol metabolic process
D	0006693	biological_process	prostaglandin metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0032866	molecular_function	D-xylose reductase (NADPH) activity
D	0032867	molecular_function	L-arabinose reductase (NADPH) activity
D	0036130	molecular_function	prostaglandin H2 endoperoxidase reductase activity
D	0042572	biological_process	retinol metabolic process
D	0047655	molecular_function	allyl-alcohol dehydrogenase activity
D	0047681	molecular_function	aryl-alcohol dehydrogenase (NADP+) activity
D	0047939	molecular_function	L-glucuronate reductase activity
D	0047956	molecular_function	glycerol dehydrogenase (NADP+) activity
D	0052650	molecular_function	all-trans-retinol dehydrogenase (NADP+) activity

Functional Information from PROSITE/UniProt

site_id	PS00062
Number of Residues	18
Details	ALDOKETO_REDUCTASE_2 Aldo/keto reductase family signature 2. MeelvdeglVKAIGVSNF

Chain	Residue	Details
A	MET143-PHE160

site_id	PS00063
Number of Residues	16
Details	ALDOKETO_REDUCTASE_3 Aldo/keto reductase family putative active site signature. IPKSVTpeRIaENfQV

Chain	Residue	Details
A	ILE259-VAL274

site_id	PS00798
Number of Residues	18
Details	ALDOKETO_REDUCTASE_1 Aldo/keto reductase family signature 1. GYRHIDCAhvyqnEneVG

Chain	Residue	Details
A	GLY37-GLY54

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P15121","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07943","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P15121","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	62
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P15121","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
A	HIS109
A	ASP42
A	LYS76
A	TYR47

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
B	HIS109
B	ASP42
B	LYS76
B	TYR47

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
C	HIS109
C	ASP42
C	LYS76
C	TYR47

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
D	HIS109
D	ASP42
D	LYS76
D	TYR47

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
A	TYR47
A	LYS76

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
B	TYR47
B	LYS76

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
C	TYR47
C	LYS76

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1mrq

Chain	Residue	Details
D	TYR47
D	LYS76

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)