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1DKT

CKSHS1: HUMAN CYCLIN DEPENDENT KINASE SUBUNIT, TYPE 1 COMPLEX WITH METAVANADATE

Functional Information from GO Data
ChainGOidnamespacecontents
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0006355biological_processregulation of DNA-templated transcription
A0007346biological_processregulation of mitotic cell cycle
A0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
A0019005cellular_componentSCF ubiquitin ligase complex
A0019901molecular_functionprotein kinase binding
A0042393molecular_functionhistone binding
A0043130molecular_functionubiquitin binding
A0044772biological_processmitotic cell cycle phase transition
A0048144biological_processfibroblast proliferation
A0051301biological_processcell division
A0061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
B0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0006355biological_processregulation of DNA-templated transcription
B0007346biological_processregulation of mitotic cell cycle
B0016538molecular_functioncyclin-dependent protein serine/threonine kinase regulator activity
B0019005cellular_componentSCF ubiquitin ligase complex
B0019901molecular_functionprotein kinase binding
B0042393molecular_functionhistone binding
B0043130molecular_functionubiquitin binding
B0044772biological_processmitotic cell cycle phase transition
B0048144biological_processfibroblast proliferation
B0051301biological_processcell division
B0061575molecular_functioncyclin-dependent protein serine/threonine kinase activator activity
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE V7O A 100
ChainResidue
AARG71
AHOH551
AHOH552
AHOH556
AHOH557
AHOH559
AHOH560
AHOH581
AHOH582
AHOH583
BLYS11
BARG20
BSER51
BTRP54
BARG71
ALYS11
AARG20
ASER51
ATRP54

site_idVO7
Number of Residues5
Details
ChainResidue
ALYS11
AARG20
ASER51
ATRP54
AARG71

Functional Information from PROSITE/UniProt
site_idPS00944
Number of Residues19
DetailsCKS_1 Cyclin-dependent kinases regulatory subunits signature 1. YSdKYdDEeFEYRHVmLPK
ChainResidueDetails
ATYR8-LYS26

site_idPS00945
Number of Residues11
DetailsCKS_2 Cyclin-dependent kinases regulatory subunits signature 2. HePEpHILLFR
ChainResidueDetails
AHIS60-ARG70

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378
ChainResidueDetails
ASER2
BSER2

227344

PDB entries from 2024-11-13

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