Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070401 | molecular_function | NADP+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 32 |
| Details | BINDING SITE FOR RESIDUE NDP A 200 |
| Chain | Residue |
| A | TRP6 |
| A | THR46 |
| A | SER49 |
| A | LEU65 |
| A | SER66 |
| A | ARG67 |
| A | GLN68 |
| A | GLY80 |
| A | ILE94 |
| A | GLY95 |
| A | GLY96 |
| A | ALA7 |
| A | GLY97 |
| A | GLN98 |
| A | VAL99 |
| A | TYR100 |
| A | LEU102 |
| A | ALA126 |
| A | TOP201 |
| A | GOL202 |
| A | HOH228 |
| A | HOH236 |
| A | ILE14 |
| A | HOH259 |
| A | HOH264 |
| A | HOH276 |
| A | GLY15 |
| A | GLY18 |
| A | ASP19 |
| A | GLY43 |
| A | ARG44 |
| A | ARG45 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE TOP A 201 |
| Chain | Residue |
| A | ILE5 |
| A | TRP6 |
| A | ASP27 |
| A | PHE31 |
| A | SER49 |
| A | LEU50 |
| A | ILE94 |
| A | TYR100 |
| A | NDP200 |
| A | GOL203 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 202 |
| Chain | Residue |
| A | ARG45 |
| A | GLN98 |
| A | GLY124 |
| A | ALA126 |
| A | GLY148 |
| A | LEU149 |
| A | NDP200 |
| A | HOH210 |
| A | HOH215 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 203 |
| Chain | Residue |
| A | PHE31 |
| A | ARG60 |
| A | TOP201 |
| A | HOH304 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 204 |
| Chain | Residue |
| A | ALA101 |
| A | ALA128 |
| A | PRO129 |
| A | VAL130 |
| A | ARG150 |
| A | HOH207 |
| A | HOH299 |
| A | HOH305 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrggdIPWrlpe.DqahFreiT |
| Chain | Residue | Details |
| A | VAL13-THR35 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ALA7 | |
| A | GLY96 | |
| A | LEU102 | |
| A | VAL115 | |
| A | GLN8 | |
| A | ARG16 | |
| A | ALA29 | |
| A | ILE34 | |
| A | ARG45 | |
| A | ASN62 | |
| A | ARG67 | |
| A | LEU82 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dhf |
| Chain | Residue | Details |
| A | ILE20 | |
| A | ASP27 | |
