1DFP
FACTOR D INHIBITED BY DIISOPROPYL FLUOROPHOSPHATE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004252 | molecular_function | serine-type endopeptidase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0005615 | cellular_component | extracellular space |
A | 0006508 | biological_process | proteolysis |
A | 0006956 | biological_process | complement activation |
A | 0006957 | biological_process | complement activation, alternative pathway |
A | 0008236 | molecular_function | serine-type peptidase activity |
A | 0009617 | biological_process | response to bacterium |
A | 0031093 | cellular_component | platelet alpha granule lumen |
A | 0034774 | cellular_component | secretory granule lumen |
A | 0070062 | cellular_component | extracellular exosome |
A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
B | 0004252 | molecular_function | serine-type endopeptidase activity |
B | 0005576 | cellular_component | extracellular region |
B | 0005615 | cellular_component | extracellular space |
B | 0006508 | biological_process | proteolysis |
B | 0006956 | biological_process | complement activation |
B | 0006957 | biological_process | complement activation, alternative pathway |
B | 0008236 | molecular_function | serine-type peptidase activity |
B | 0009617 | biological_process | response to bacterium |
B | 0031093 | cellular_component | platelet alpha granule lumen |
B | 0034774 | cellular_component | secretory granule lumen |
B | 0070062 | cellular_component | extracellular exosome |
B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE DFP A 500 |
Chain | Residue |
A | LYS192 |
A | GLY193 |
A | SER195 |
A | THR214 |
A | SER215 |
A | GLY216 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE DFP B 501 |
Chain | Residue |
B | GLY193 |
B | ASP194 |
B | SER195 |
B | THR214 |
B | SER215 |
B | GLY216 |
B | LYS192 |
site_id | S1 |
Number of Residues | 1 |
Details | DIISOPROPYL FLUOROPHOSPHORYL MOIETY LINKED TO O ATOM OF SER 195 IN BOTH CHAINS. |
Chain | Residue |
A | DFP500 |
site_id | S2 |
Number of Residues | 1 |
Details | DIISOPROPYL FLUOROPHOSPHORYL MOIETY LINKED TO O ATOM OF SER 195 IN BOTH CHAINS. |
Chain | Residue |
B | DFP501 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | ACT_SITE: Charge relay system |
Chain | Residue | Details |
A | HIS57 | |
A | ASP102 | |
A | SER195 | |
B | HIS57 | |
B | ASP102 | |
B | SER195 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
A | ASP102 | |
A | SER195 | |
A | HIS57 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | ASP102 | |
B | SER195 | |
B | HIS57 |
site_id | CSA3 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
A | ASP102 | |
A | SER195 | |
A | GLY193 | |
A | HIS57 |
site_id | CSA4 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | ASP102 | |
B | SER195 | |
B | GLY193 | |
B | HIS57 |
site_id | CSA5 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
A | ASP102 | |
A | SER195 | |
A | HIS57 | |
A | GLY196 |
site_id | CSA6 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | ASP102 | |
B | SER195 | |
B | HIS57 | |
B | GLY196 |
site_id | CSA7 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
A | SER195 | |
A | GLY193 | |
A | HIS57 | |
A | ASP93 |
site_id | CSA8 |
Number of Residues | 4 |
Details | Annotated By Reference To The Literature 1a0j |
Chain | Residue | Details |
B | SER195 | |
B | GLY193 | |
B | HIS57 | |
B | ASP93 |