1DEG

THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000922	cellular_component	spindle pole
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0019904	molecular_function	protein domain specific binding
A	0032991	cellular_component	protein-containing complex
A	0046872	molecular_function	metal ion binding
A	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
A	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 1

Chain	Residue
A	ILE27

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CA A 3

Chain	Residue
A	ILE100

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site_id	EF1
Number of Residues	12
Details

Chain	Residue
A	ASP20
A	THR29
A	LYS30
A	GLU31
A	LYS21
A	ASP22
A	GLY23
A	ASP24
A	GLY25
A	THR26
A	ILE27
A	THR28

---

site_id	EF2
Number of Residues	12
Details

Chain	Residue
A	ASP56
A	ALA57
A	ASP58
A	GLY59
A	ASN60
A	GLY61
A	THR62
A	ILE63
A	ASP64
A	PHE65
A	PRO66
A	GLU67

---

site_id	EF3
Number of Residues	12
Details

Chain	Residue
A	ASP93
A	LYS94
A	ASP95
A	GLY96
A	ASN97
A	GLY98
A	TYR99
A	ILE100
A	SER101
A	ALA102
A	ALA103
A	GLU104

---

site_id	EF4
Number of Residues	12
Details

Chain	Residue
A	ASN129
A	ILE130
A	ASP131
A	GLY132
A	ASP133
A	GLY134
A	GLN135
A	VAL136
A	ASN137
A	TYR138
A	GLU139
A	GLU140

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
A	ASP20-LEU32
A	ASP56-PHE68
A	ASP93-LEU105

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448

Chain	Residue	Details
A	LYS21
A	PHE68
A	ASP95
A	ASN97
A	TYR99
A	SER101
A	ARG106
A	ASP131
A	ASP133
A	GLN135
A	ASN137
A	GLY23
A	VAL142
A	GLY25
A	ILE27
A	LEU32
A	ALA57
A	GLY59
A	GLY61
A	ILE63

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	THR117

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	ASP22

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29

Chain	Residue	Details
A	GLU45

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	GLU82
A	ALA103

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	GLY96

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	SER101
A	GLU140

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P0DP23

Chain	Residue	Details
A	LEU112

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site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:9716384

Chain	Residue	Details
A	ASP22

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