1DCT
DNA (CYTOSINE-5) METHYLASE FROM HAEIII COVALENTLY BOUND TO DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003886 | molecular_function | DNA (cytosine-5-)-methyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009307 | biological_process | DNA restriction-modification system |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0044027 | biological_process | negative regulation of gene expression via chromosomal CpG island methylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003886 | molecular_function | DNA (cytosine-5-)-methyltransferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009307 | biological_process | DNA restriction-modification system |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0044027 | biological_process | negative regulation of gene expression via chromosomal CpG island methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA A 1001 |
| Chain | Residue |
| A | ASN166 |
| B | GLU233 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA B 1002 |
| Chain | Residue |
| B | ASN166 |
| M | DG17 |
| site_id | DAA |
| Number of Residues | 8 |
| Details |
| Chain | Residue |
| F | DG8 |
| F | DG9 |
| F | C4910 |
| F | DC11 |
| M | DC12 |
| M | 5CM11 |
| M | DG10 |
| M | DG9 |
| site_id | DAB |
| Number of Residues | 8 |
| Details |
| Chain | Residue |
| G | DG9 |
| G | C4910 |
| G | DC11 |
| N | DC12 |
| N | 5CM11 |
| N | DG10 |
| N | DG9 |
| G | DG8 |
Functional Information from PROSITE/UniProt
| site_id | PS00094 |
| Number of Residues | 13 |
| Details | C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. DgIigGpPCqSWS |
| Chain | Residue | Details |
| A | ASP63-SER75 |
| site_id | PS00095 |
| Number of Residues | 19 |
| Details | C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. KmiGNAVpVnLayeIaktI |
| Chain | Residue | Details |
| A | LYS302-ILE320 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01016","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10018","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1932026","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3UBT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mht |
| Chain | Residue | Details |
| A | GLU109 | |
| A | CYS71 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1mht |
| Chain | Residue | Details |
| B | GLU109 | |
| B | CYS71 |
