1DCH
CRYSTAL STRUCTURE OF DCOH, A BIFUNCTIONAL, PROTEIN-BINDING TRANSCRIPTION COACTIVATOR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003713 | molecular_function | transcription coactivator activity |
| A | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006558 | biological_process | L-phenylalanine metabolic process |
| A | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| A | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| A | 0008150 | biological_process | biological_process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043393 | biological_process | regulation of protein binding |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0003713 | molecular_function | transcription coactivator activity |
| B | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006558 | biological_process | L-phenylalanine metabolic process |
| B | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| B | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| B | 0008150 | biological_process | biological_process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043393 | biological_process | regulation of protein binding |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| C | 0003713 | molecular_function | transcription coactivator activity |
| C | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006558 | biological_process | L-phenylalanine metabolic process |
| C | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| C | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| C | 0008150 | biological_process | biological_process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043393 | biological_process | regulation of protein binding |
| C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| D | 0003713 | molecular_function | transcription coactivator activity |
| D | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006558 | biological_process | L-phenylalanine metabolic process |
| D | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| D | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| D | 0008150 | biological_process | biological_process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0043393 | biological_process | regulation of protein binding |
| D | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| E | 0003713 | molecular_function | transcription coactivator activity |
| E | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006558 | biological_process | L-phenylalanine metabolic process |
| E | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| E | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| E | 0008150 | biological_process | biological_process |
| E | 0016829 | molecular_function | lyase activity |
| E | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0043393 | biological_process | regulation of protein binding |
| E | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| F | 0003713 | molecular_function | transcription coactivator activity |
| F | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006558 | biological_process | L-phenylalanine metabolic process |
| F | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| F | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| F | 0008150 | biological_process | biological_process |
| F | 0016829 | molecular_function | lyase activity |
| F | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0043393 | biological_process | regulation of protein binding |
| F | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| G | 0003713 | molecular_function | transcription coactivator activity |
| G | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| G | 0005634 | cellular_component | nucleus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006558 | biological_process | L-phenylalanine metabolic process |
| G | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| G | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| G | 0008150 | biological_process | biological_process |
| G | 0016829 | molecular_function | lyase activity |
| G | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0043393 | biological_process | regulation of protein binding |
| G | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| H | 0003713 | molecular_function | transcription coactivator activity |
| H | 0004505 | molecular_function | phenylalanine 4-monooxygenase activity |
| H | 0005634 | cellular_component | nucleus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006558 | biological_process | L-phenylalanine metabolic process |
| H | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| H | 0008124 | molecular_function | 4-alpha-hydroxytetrahydrobiopterin dehydratase activity |
| H | 0008150 | biological_process | biological_process |
| H | 0016829 | molecular_function | lyase activity |
| H | 0019293 | biological_process | tyrosine biosynthetic process, by oxidation of phenylalanine |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0043393 | biological_process | regulation of protein binding |
| H | 0045893 | biological_process | positive regulation of DNA-templated transcription |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 200 |
| Chain | Residue |
| A | THR79 |
| A | HIS80 |
| A | GLU81 |
| A | ARG88 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 200 |
| Chain | Residue |
| B | HIS62 |
| B | THR79 |
| B | HIS80 |
| B | ARG88 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 200 |
| Chain | Residue |
| C | THR79 |
| C | HIS80 |
| C | GLU81 |
| C | ARG88 |
| C | HIS62 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 200 |
| Chain | Residue |
| D | HIS62 |
| D | THR79 |
| D | HIS80 |
| D | GLU81 |
| D | ARG88 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 200 |
| Chain | Residue |
| E | HIS62 |
| E | THR79 |
| E | HIS80 |
| E | GLU81 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 F 200 |
| Chain | Residue |
| F | HIS62 |
| F | THR79 |
| F | HIS80 |
| F | GLU81 |
| F | ARG88 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 G 200 |
| Chain | Residue |
| G | HIS62 |
| G | HIS80 |
| G | GLU81 |
| G | ARG88 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 H 200 |
| Chain | Residue |
| H | HIS62 |
| H | THR79 |
| H | HIS80 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS62 | |
| E | THR79 | |
| F | HIS62 | |
| F | THR79 | |
| G | HIS62 | |
| G | THR79 | |
| H | HIS62 | |
| H | THR79 | |
| A | THR79 | |
| B | HIS62 | |
| B | THR79 | |
| C | HIS62 | |
| C | THR79 | |
| D | HIS62 | |
| D | THR79 | |
| E | HIS62 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:8444860 |
| Chain | Residue | Details |
| A | GLY3 | |
| B | GLY3 | |
| C | GLY3 | |
| D | GLY3 | |
| E | GLY3 | |
| F | GLY3 | |
| G | GLY3 | |
| H | GLY3 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| A | HIS80 | |
| A | HIS62 | |
| A | HIS63 | |
| A | ASP89 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| B | HIS80 | |
| B | HIS62 | |
| B | HIS63 | |
| B | ASP89 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| C | HIS80 | |
| C | HIS62 | |
| C | HIS63 | |
| C | ASP89 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| D | HIS80 | |
| D | HIS62 | |
| D | HIS63 | |
| D | ASP89 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| E | HIS80 | |
| E | HIS62 | |
| E | HIS63 | |
| E | ASP89 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| F | HIS80 | |
| F | HIS62 | |
| F | HIS63 | |
| F | ASP89 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| G | HIS80 | |
| G | HIS62 | |
| G | HIS63 | |
| G | ASP89 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1dco |
| Chain | Residue | Details |
| H | HIS80 | |
| H | HIS62 | |
| H | HIS63 | |
| H | ASP89 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| A | LYS59 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| A | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | PRO64 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| A | CYS82 | electrostatic stabiliser, hydrogen bond donor |
| A | ILE90 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| B | LYS59 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| B | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | PRO64 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| B | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| B | CYS82 | electrostatic stabiliser, hydrogen bond donor |
| B | ILE90 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA3 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| C | LYS59 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| C | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| C | PRO64 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| C | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| C | CYS82 | electrostatic stabiliser, hydrogen bond donor |
| C | ILE90 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA4 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| D | LYS59 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| D | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| D | PRO64 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| D | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| D | CYS82 | electrostatic stabiliser, hydrogen bond donor |
| D | ILE90 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA5 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| E | LYS59 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| E | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| E | PRO64 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| E | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| E | CYS82 | electrostatic stabiliser, hydrogen bond donor |
| E | ILE90 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA6 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| F | LYS59 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| F | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| F | PRO64 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| F | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| F | CYS82 | electrostatic stabiliser, hydrogen bond donor |
| F | ILE90 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA7 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| G | LYS59 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| G | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| G | PRO64 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| G | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| G | CYS82 | electrostatic stabiliser, hydrogen bond donor |
| G | ILE90 | electrostatic stabiliser, hydrogen bond acceptor |
| site_id | MCSA8 |
| Number of Residues | 6 |
| Details | M-CSA 73 |
| Chain | Residue | Details |
| H | LYS59 | electrostatic stabiliser, hydrogen bond acceptor, proton acceptor, proton donor |
| H | HIS63 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| H | PRO64 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| H | GLU81 | electrostatic stabiliser, hydrogen bond donor |
| H | CYS82 | electrostatic stabiliser, hydrogen bond donor |
| H | ILE90 | electrostatic stabiliser, hydrogen bond acceptor |
