1DCE
CRYSTAL STRUCTURE OF RAB GERANYLGERANYLTRANSFERASE FROM RAT BRAIN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0004661 | molecular_function | protein geranylgeranyltransferase activity |
| A | 0004663 | molecular_function | Rab geranylgeranyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005968 | cellular_component | Rab-protein geranylgeranyltransferase complex |
| A | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008318 | molecular_function | protein prenyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018342 | biological_process | protein prenylation |
| A | 0018344 | biological_process | protein geranylgeranylation |
| A | 0031267 | molecular_function | small GTPase binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0004661 | molecular_function | protein geranylgeranyltransferase activity |
| B | 0004663 | molecular_function | Rab geranylgeranyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005968 | cellular_component | Rab-protein geranylgeranyltransferase complex |
| B | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008318 | molecular_function | protein prenyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018344 | biological_process | protein geranylgeranylation |
| B | 0019840 | molecular_function | isoprenoid binding |
| B | 0031267 | molecular_function | small GTPase binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004659 | molecular_function | prenyltransferase activity |
| C | 0004661 | molecular_function | protein geranylgeranyltransferase activity |
| C | 0004663 | molecular_function | Rab geranylgeranyltransferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005968 | cellular_component | Rab-protein geranylgeranyltransferase complex |
| C | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0008318 | molecular_function | protein prenyltransferase activity |
| C | 0016740 | molecular_function | transferase activity |
| C | 0018342 | biological_process | protein prenylation |
| C | 0018344 | biological_process | protein geranylgeranylation |
| C | 0031267 | molecular_function | small GTPase binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004659 | molecular_function | prenyltransferase activity |
| D | 0004661 | molecular_function | protein geranylgeranyltransferase activity |
| D | 0004663 | molecular_function | Rab geranylgeranyltransferase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005968 | cellular_component | Rab-protein geranylgeranyltransferase complex |
| D | 0006888 | biological_process | endoplasmic reticulum to Golgi vesicle-mediated transport |
| D | 0008270 | molecular_function | zinc ion binding |
| D | 0008318 | molecular_function | protein prenyltransferase activity |
| D | 0016740 | molecular_function | transferase activity |
| D | 0018344 | biological_process | protein geranylgeranylation |
| D | 0019840 | molecular_function | isoprenoid binding |
| D | 0031267 | molecular_function | small GTPase binding |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 900 |
| Chain | Residue |
| A | HIS2 |
| B | ASP238 |
| B | CYS240 |
| B | HIS290 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 950 |
| Chain | Residue |
| C | HIS2 |
| D | ASP238 |
| D | CYS240 |
| D | HIS290 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 68 |
| Details | Repeat: {"description":"PFTA 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 68 |
| Details | Repeat: {"description":"PFTA 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 68 |
| Details | Repeat: {"description":"PFTA 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 68 |
| Details | Repeat: {"description":"PFTA 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 68 |
| Details | Repeat: {"description":"PFTA 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 68 |
| Details | Repeat: {"description":"PFTA 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"LRR 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"LRR 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9JHK4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"PFTB 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"PFTB 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"PFTB 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"PFTB 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 82 |
| Details | Repeat: {"description":"PFTB 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"PFTB 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18756270","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3DST","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DSX","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18399557","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18756270","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19894725","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22480322","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22963166","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI21 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3DST","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3DSV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI22 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P53611","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d8d |
| Chain | Residue | Details |
| A | LYS105 | |
| B | TYR241 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1d8d |
| Chain | Residue | Details |
| A | SER176 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d8d |
| Chain | Residue | Details |
| C | LYS105 | |
| D | TYR241 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1d8d |
| Chain | Residue | Details |
| C | SER176 |
