1DCE

CRYSTAL STRUCTURE OF RAB GERANYLGERANYLTRANSFERASE FROM RAT BRAIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004659	molecular_function	prenyltransferase activity
A	0004661	molecular_function	protein geranylgeranyltransferase activity
A	0004663	molecular_function	Rab geranylgeranyltransferase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
A	0008270	molecular_function	zinc ion binding
A	0008318	molecular_function	protein prenyltransferase activity
A	0018342	biological_process	protein prenylation
A	0018344	biological_process	protein geranylgeranylation
A	0031267	molecular_function	small GTPase binding
B	0003824	molecular_function	catalytic activity
B	0004659	molecular_function	prenyltransferase activity
B	0004661	molecular_function	protein geranylgeranyltransferase activity
B	0004663	molecular_function	Rab geranylgeranyltransferase activity
B	0005515	molecular_function	protein binding
B	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
B	0008270	molecular_function	zinc ion binding
B	0008318	molecular_function	protein prenyltransferase activity
B	0018344	biological_process	protein geranylgeranylation
B	0019840	molecular_function	isoprenoid binding
B	0031267	molecular_function	small GTPase binding
B	0046872	molecular_function	metal ion binding
C	0004659	molecular_function	prenyltransferase activity
C	0004661	molecular_function	protein geranylgeranyltransferase activity
C	0004663	molecular_function	Rab geranylgeranyltransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
C	0008270	molecular_function	zinc ion binding
C	0008318	molecular_function	protein prenyltransferase activity
C	0018342	biological_process	protein prenylation
C	0018344	biological_process	protein geranylgeranylation
C	0031267	molecular_function	small GTPase binding
D	0003824	molecular_function	catalytic activity
D	0004659	molecular_function	prenyltransferase activity
D	0004661	molecular_function	protein geranylgeranyltransferase activity
D	0004663	molecular_function	Rab geranylgeranyltransferase activity
D	0005515	molecular_function	protein binding
D	0005968	cellular_component	Rab-protein geranylgeranyltransferase complex
D	0008270	molecular_function	zinc ion binding
D	0008318	molecular_function	protein prenyltransferase activity
D	0018344	biological_process	protein geranylgeranylation
D	0019840	molecular_function	isoprenoid binding
D	0031267	molecular_function	small GTPase binding
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 900

Chain	Residue
A	HIS2
B	ASP238
B	CYS240
B	HIS290

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 950

Chain	Residue
C	HIS2
D	ASP238
D	CYS240
D	HIS290

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:18756270, ECO:0007744|PDB:3DST, ECO:0007744|PDB:3DSX

Chain	Residue	Details
B	HIS190
D	HIS190

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:18399557, ECO:0000269|PubMed:18756270, ECO:0000269|PubMed:19894725, ECO:0000269|PubMed:22480322, ECO:0000269|PubMed:22963166

Chain	Residue	Details
B	ASP238
B	CYS240
B	HIS290
D	ASP238
D	CYS240
D	HIS290

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:3DST, ECO:0007744|PDB:3DSV

Chain	Residue	Details
B	TYR241
D	TYR241

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N-acetylglycine => ECO:0000250|UniProtKB:P53611

Chain	Residue	Details
B	GLY2
D	GLY2

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P53611

Chain	Residue	Details
B	THR3
D	THR3

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
A	LYS105
B	TYR241

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
A	SER176

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site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
C	LYS105
D	TYR241

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site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1d8d

Chain	Residue	Details
C	SER176

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