Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1DBR

HYPOXANTHINE GUANINE XANTHINE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0000310	molecular_function	xanthine phosphoribosyltransferase activity
A	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0006178	biological_process	guanine salvage
A	0016757	molecular_function	glycosyltransferase activity
A	0032263	biological_process	GMP salvage
A	0032264	biological_process	IMP salvage
A	0032265	biological_process	XMP salvage
A	0046100	biological_process	hypoxanthine metabolic process
A	0046872	molecular_function	metal ion binding
A	0052657	molecular_function	guanine phosphoribosyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0000310	molecular_function	xanthine phosphoribosyltransferase activity
B	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0006178	biological_process	guanine salvage
B	0016757	molecular_function	glycosyltransferase activity
B	0032263	biological_process	GMP salvage
B	0032264	biological_process	IMP salvage
B	0032265	biological_process	XMP salvage
B	0046100	biological_process	hypoxanthine metabolic process
B	0046872	molecular_function	metal ion binding
B	0052657	molecular_function	guanine phosphoribosyltransferase activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0000310	molecular_function	xanthine phosphoribosyltransferase activity
C	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0006178	biological_process	guanine salvage
C	0016757	molecular_function	glycosyltransferase activity
C	0032263	biological_process	GMP salvage
C	0032264	biological_process	IMP salvage
C	0032265	biological_process	XMP salvage
C	0046100	biological_process	hypoxanthine metabolic process
C	0046872	molecular_function	metal ion binding
C	0052657	molecular_function	guanine phosphoribosyltransferase activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0000310	molecular_function	xanthine phosphoribosyltransferase activity
D	0004422	molecular_function	hypoxanthine phosphoribosyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0006178	biological_process	guanine salvage
D	0016757	molecular_function	glycosyltransferase activity
D	0032263	biological_process	GMP salvage
D	0032264	biological_process	IMP salvage
D	0032265	biological_process	XMP salvage
D	0046100	biological_process	hypoxanthine metabolic process
D	0046872	molecular_function	metal ion binding
D	0052657	molecular_function	guanine phosphoribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 232

Chain	Residue
A	GLU146
A	ASP147
A	ILE148
A	HOH323

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B 232

Chain	Residue
B	GLU146
B	ASP147

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG C 232

Chain	Residue
C	GLU146
C	ASP147

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG D 232

Chain	Residue
D	ASP147
D	GLU146

Functional Information from PROSITE/UniProt

site_id	PS00103
Number of Residues	13
Details	PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VLIVEDIVDTGfT

Chain	Residue	Details
A	VAL142-THR154

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:10545171, ECO:0000269\|PubMed:11188695

Chain	Residue	Details
A	ASP150
B	ASP150
C	ASP150
D	ASP150

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING:

Chain	Residue	Details
A	LYS79
C	GLU146
C	LYS178
C	TRP199
D	LYS79
D	GLU146
D	LYS178
D	TRP199
A	GLU146
A	LYS178
A	TRP199
B	LYS79
B	GLU146
B	LYS178
B	TRP199
C	LYS79

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269\|PubMed:11188695

Chain	Residue	Details
A	ASP206
B	ASP206
C	ASP206
D	ASP206

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
A	ASP147
A	ASP150
A	GLU146
A	LYS178

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
B	ASP147
B	ASP150
B	GLU146
B	LYS178

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
C	ASP147
C	ASP150
C	GLU146
C	LYS178

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
D	ASP147
D	ASP150
D	GLU146
D	LYS178

site_id	CSA5
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
A	ARG182
A	ASP147
A	ASP150
A	GLU146
A	LYS178

site_id	CSA6
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
B	ARG182
B	ASP147
B	ASP150
B	GLU146
B	LYS178

site_id	CSA7
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
C	ARG182
C	ASP147
C	ASP150
C	GLU146
C	LYS178

site_id	CSA8
Number of Residues	5
Details	Annotated By Reference To The Literature 1a95

Chain	Residue	Details
D	ARG182
D	ASP147
D	ASP150
D	GLU146
D	LYS178

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)