1DB5
HUMAN S-PLA2 IN COMPLEX WITH INDOLE 6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | A2-type glycerophospholipase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0010744 | biological_process | positive regulation of macrophage derived foam cell differentiation |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0034374 | biological_process | low-density lipoprotein particle remodeling |
| A | 0036335 | biological_process | intestinal stem cell homeostasis |
| A | 0038166 | biological_process | angiotensin-activated signaling pathway |
| A | 0042130 | biological_process | negative regulation of T cell proliferation |
| A | 0046337 | biological_process | phosphatidylethanolamine metabolic process |
| A | 0046470 | biological_process | phosphatidylcholine metabolic process |
| A | 0046471 | biological_process | phosphatidylglycerol metabolic process |
| A | 0046473 | biological_process | phosphatidic acid metabolic process |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050482 | biological_process | arachidonate secretion |
| A | 0050729 | biological_process | positive regulation of inflammatory response |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 1902563 | biological_process | regulation of neutrophil activation |
| A | 1904109 | biological_process | positive regulation of cholesterol import |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 198 |
| Chain | Residue |
| A | HIS27 |
| A | GLY29 |
| A | GLY31 |
| A | ASP48 |
| A | 6IN200 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 199 |
| Chain | Residue |
| A | HOH237 |
| A | PHE23 |
| A | GLY25 |
| A | TYR112 |
| A | ASN114 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 6IN A 200 |
| Chain | Residue |
| A | LEU2 |
| A | HIS6 |
| A | LEU19 |
| A | TYR21 |
| A | HIS27 |
| A | CYS28 |
| A | GLY29 |
| A | VAL30 |
| A | GLY31 |
| A | CYS44 |
| A | HIS47 |
| A | ASP48 |
| A | TYR51 |
| A | LYS52 |
| A | LYS62 |
| A | CA198 |
| A | HOH236 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"1948070","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7664108","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DB4","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1DB5","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1DCY","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1POE","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Important for integrin binding","evidences":[{"source":"PubMed","id":"18635536","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| A | HIS47 | |
| A | ASP91 | |
| A | GLY29 |
