1D6S
CRYSTAL STRUCTURE OF THE K41A MUTANT OF O-ACETYLSERINE SULFHYDRYLASE COMPLEXED IN EXTERNAL ALDIMINE LINKAGE WITH METHIONINE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004124 | molecular_function | cysteine synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004124 | molecular_function | cysteine synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006535 | biological_process | cysteine biosynthetic process from serine |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0019344 | biological_process | cysteine biosynthetic process |
| B | 0080146 | molecular_function | L-cysteine desulfhydrase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MET A 401 |
| Chain | Residue |
| A | THR68 |
| A | ASN69 |
| A | GLY70 |
| A | ASN71 |
| A | THR72 |
| A | GLN142 |
| A | GLY228 |
| A | PLP501 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE PLP A 501 |
| Chain | Residue |
| A | ASN71 |
| A | GLY176 |
| A | THR177 |
| A | GLY178 |
| A | GLY179 |
| A | THR180 |
| A | GLY228 |
| A | ILE229 |
| A | SER272 |
| A | PRO299 |
| A | SER300 |
| A | TYR305 |
| A | MET401 |
| A | HOH508 |
| A | HOH579 |
| A | ASN69 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PLP B 502 |
| Chain | Residue |
| B | ASN69 |
| B | ASN71 |
| B | GLY174 |
| B | GLY176 |
| B | THR177 |
| B | GLY178 |
| B | THR180 |
| B | GLN227 |
| B | GLY228 |
| B | ILE229 |
| B | SER272 |
| B | PRO299 |
| B | SER300 |
| B | TYR305 |
| B | MET402 |
| B | HOH509 |
| B | HOH514 |
| B | HOH565 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MET B 402 |
| Chain | Residue |
| B | THR68 |
| B | ASN69 |
| B | GLY70 |
| B | ASN71 |
| B | THR72 |
| B | MET119 |
| B | GLN142 |
| B | GLY228 |
| B | PLP502 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11023792","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"11023792","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10452898","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11023792","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9761678","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine"} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| A | SER272 | |
| A | ALA41 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| B | SER272 | |
| B | ALA41 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| A | ALA41 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oas |
| Chain | Residue | Details |
| B | ALA41 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 865 |
| Chain | Residue | Details |
| A | ALA41 | covalent catalysis, proton shuttle (general acid/base) |
| A | SER272 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 865 |
| Chain | Residue | Details |
| B | ALA41 | covalent catalysis, proton shuttle (general acid/base) |
| B | SER272 | electrostatic stabiliser |
