1D6A

STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN COMPLEXED WITH GUANINE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006952	biological_process	defense response
A	0016787	molecular_function	hydrolase activity
A	0017148	biological_process	negative regulation of translation
A	0030598	molecular_function	rRNA N-glycosylase activity
A	0035821	biological_process	modulation of process of another organism
A	0051607	biological_process	defense response to virus
A	0090729	molecular_function	toxin activity
B	0006952	biological_process	defense response
B	0016787	molecular_function	hydrolase activity
B	0017148	biological_process	negative regulation of translation
B	0030598	molecular_function	rRNA N-glycosylase activity
B	0035821	biological_process	modulation of process of another organism
B	0051607	biological_process	defense response to virus
B	0090729	molecular_function	toxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GUN A 901

Chain	Residue
A	TYR72
A	VAL73
A	SER121
A	TYR123
A	ILE171
A	GLU176
A	ARG179
A	HOH1057

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GUN B 902

Chain	Residue
B	VAL73
B	SER121
B	TYR123
B	ILE171
B	GLU176
B	ARG179
B	HOH1105
B	TYR72

---

Functional Information from PROSITE/UniProt

site_id	PS00275
Number of Residues	17
Details	SHIGA_RICIN Shiga/ricin ribosomal inactivating toxins active site signature. IqMVsEAARFKyIEnqV

Chain	Residue	Details
A	ILE171-VAL187

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P84531","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10493577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10595542","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8411176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QCI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QCJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10493577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10595542","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8411176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QCJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10493577","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1QCJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10493577","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10595542","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8411176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1D6A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1QCI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1abr

Chain	Residue	Details
A	ARG179
A	GLU176

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1abr

Chain	Residue	Details
B	ARG179
B	GLU176

---