1D5F
STRUCTURE OF E6AP: INSIGHTS INTO UBIQUITINATION PATHWAY
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000209 | biological_process | protein polyubiquitination |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0061630 | molecular_function | ubiquitin protein ligase activity |
| B | 0000209 | biological_process | protein polyubiquitination |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0061630 | molecular_function | ubiquitin protein ligase activity |
| C | 0000209 | biological_process | protein polyubiquitination |
| C | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| C | 0061630 | molecular_function | ubiquitin protein ligase activity |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Glycyl thioester intermediate |
| Chain | Residue | Details |
| A | ILE843 | |
| B | ILE843 | |
| C | ILE843 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphotyrosine; by ABL1 => ECO:0000269|PubMed:23581475 |
| Chain | Residue | Details |
| A | ILE659 | |
| B | ILE659 | |
| C | ILE659 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1c4z |
| Chain | Residue | Details |
| A | GLU550 | |
| A | ARG506 | |
| A | CYS820 | |
| A | HIS818 | |
| A | GLU539 | |
| A | ASP607 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1c4z |
| Chain | Residue | Details |
| B | GLU550 | |
| B | ARG506 | |
| B | CYS820 | |
| B | HIS818 | |
| B | GLU539 | |
| B | ASP607 |
| site_id | CSA3 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1c4z |
| Chain | Residue | Details |
| C | GLU550 | |
| C | ARG506 | |
| C | CYS820 | |
| C | HIS818 | |
| C | GLU539 | |
| C | ASP607 |
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 438 |
| Chain | Residue | Details |
| A | ARG506 | unknown |
| A | GLU539 | unknown |
| A | GLU550 | unknown |
| A | ASP607 | electrostatic stabiliser |
| A | HIS818 | |
| A | CYS820 | covalent catalysis |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 438 |
| Chain | Residue | Details |
| B | ARG506 | unknown |
| B | GLU539 | unknown |
| B | GLU550 | unknown |
| B | ASP607 | electrostatic stabiliser |
| B | HIS818 | |
| B | CYS820 | covalent catalysis |
| site_id | MCSA3 |
| Number of Residues | 6 |
| Details | M-CSA 438 |
| Chain | Residue | Details |
| C | ARG506 | unknown |
| C | GLU539 | unknown |
| C | GLU550 | unknown |
| C | ASP607 | electrostatic stabiliser |
| C | HIS818 | |
| C | CYS820 | covalent catalysis |
