1D2E

CRYSTAL STRUCTURE OF MITOCHONDRIAL EF-TU IN COMPLEX WITH GDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0006414	biological_process	translational elongation
B	0003746	molecular_function	translation elongation factor activity
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0006414	biological_process	translational elongation
C	0003746	molecular_function	translation elongation factor activity
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding
C	0006414	biological_process	translational elongation
D	0003746	molecular_function	translation elongation factor activity
D	0003924	molecular_function	GTPase activity
D	0005525	molecular_function	GTP binding
D	0006414	biological_process	translational elongation

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 501

Chain	Residue
A	THR71
A	GDP1301
A	HOH1685
A	HOH1686
A	HOH1687
A	HOH1688

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 502

Chain	Residue
B	HOH1574
B	HOH1575
B	HOH1576
B	THR71
B	GDP1302
B	HOH1573

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 503

Chain	Residue
C	THR71
C	GDP1303
C	HOH1595
C	HOH1596
C	HOH1597
C	HOH1598

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 504

Chain	Residue
D	THR71
D	GDP1304
D	HOH1548
D	HOH1549

---

site_id	AC5
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GDP A 1301

Chain	Residue
A	HIS65
A	ASP67
A	HIS68
A	GLY69
A	LYS70
A	THR71
A	THR72
A	TYR92
A	ASN181
A	LYS182
A	ASP184
A	SER219
A	ALA220
A	LEU221
A	MG501
A	HOH1324
A	HOH1335
A	HOH1336
A	HOH1353
A	HOH1380
A	HOH1417
A	HOH1523
A	HOH1686
A	HOH1688

---

site_id	AC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GDP B 1302

Chain	Residue
B	ASP67
B	HIS68
B	GLY69
B	LYS70
B	THR71
B	THR72
B	TYR92
B	ASN181
B	LYS182
B	ASP184
B	SER219
B	ALA220
B	LEU221
B	MG502
B	HOH1395
B	HOH1529
B	HOH1574
B	HOH1576

---

site_id	AC7
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GDP C 1303

Chain	Residue
C	VAL66
C	ASP67
C	HIS68
C	GLY69
C	LYS70
C	THR71
C	THR72
C	TYR92
C	ASN181
C	LYS182
C	ASP184
C	SER219
C	ALA220
C	LEU221
C	MG503
C	HOH1356
C	HOH1517
C	HOH1550
C	HOH1551
C	HOH1564
C	HOH1596
C	HOH1598

---

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GDP D 1304

Chain	Residue
D	MG504
D	HOH1368
D	HOH1548
D	ASP67
D	HIS68
D	GLY69
D	LYS70
D	THR71
D	THR72
D	TYR92
D	ASN181
D	LYS182
D	ASP184
D	SER219
D	ALA220
D	LEU221

---

Functional Information from PROSITE/UniProt

site_id	PS00301
Number of Residues	16
Details	G_TR_1 Translational (tr)-type guanine nucleotide-binding (G) domain signature. DNapeERaRGITInaA

Chain	Residue	Details
A	ASP96-ALA111

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0CE47

Chain	Residue	Details
A	ASP67
A	LEU221
B	ASP67
B	GLY69
B	LYS70
B	THR71
B	THR72
B	ASN181
B	ASP184
B	SER219
B	ALA220
A	GLY69
B	LEU221
C	ASP67
C	GLY69
C	LYS70
C	THR71
C	THR72
C	ASN181
C	ASP184
C	SER219
C	ALA220
A	LYS70
C	LEU221
D	ASP67
D	GLY69
D	LYS70
D	THR71
D	THR72
D	ASN181
D	ASP184
D	SER219
D	ALA220
A	THR71
D	LEU221
A	THR72
A	ASN181
A	ASP184
A	SER219
A	ALA220

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P49411

Chain	Residue	Details
A	LYS79
D	LYS79
D	LYS256
D	LYS418
A	LYS256
A	LYS418
B	LYS79
B	LYS256
B	LYS418
C	LYS79
C	LYS256
C	LYS418

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8BFR5

Chain	Residue	Details
A	LYS88
B	LYS88
C	LYS88
D	LYS88

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8BFR5

Chain	Residue	Details
A	LYS234
A	LYS286
B	LYS234
B	LYS286
C	LYS234
C	LYS286
D	LYS234
D	LYS286

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P49411

Chain	Residue	Details
A	THR278
B	THR278
C	THR278
D	THR278

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8BFR5

Chain	Residue	Details
A	SER312
B	SER312
C	SER312
D	SER312

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8BFR5

Chain	Residue	Details
A	LYS361
B	LYS361
C	LYS361
D	LYS361

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	ASP67

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	ASP67

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	ASP67

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	ASP67

---

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	HIS130

---

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	HIS130

---

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	HIS130

---

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	HIS130

---