1D1P

CRYSTAL STRUCTURE OF A YEAST LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE (LTP1)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003993	molecular_function	acid phosphatase activity
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006470	biological_process	protein dephosphorylation
B	0003993	molecular_function	acid phosphatase activity
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004725	molecular_function	protein tyrosine phosphatase activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006470	biological_process	protein dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE EPE A 201

Chain	Residue
A	CYS13
A	TRP134
A	HOH227
B	TYR51
A	LEU14
A	GLY15
A	ASN16
A	PHE17
A	CYS18
A	ARG19
A	HIS52
A	ASP132

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE EPE B 202

Chain	Residue
A	HOH218
B	CYS13
B	LEU14
B	GLY15
B	ASN16
B	PHE17
B	CYS18
B	ARG19
B	HIS52
B	ASP132
B	TRP134
B	HOH210

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:10684639, ECO:0007744|PDB:1D1Q

Chain	Residue	Details
A	CYS13
B	CYS13

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Transition state stabilizer => ECO:0000269|PubMed:10684639, ECO:0007744|PDB:1D1Q

Chain	Residue	Details
A	ARG19
B	ARG19

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000269|PubMed:10684639, ECO:0007744|PDB:1D1Q

Chain	Residue	Details
A	ASP132
B	ASP132

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Important for catalytic activity => ECO:0000269|PubMed:10684639, ECO:0007744|PDB:1D1Q

Chain	Residue	Details
A	SER20
B	SER20

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	SER56
B	SER56

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1pnt

Chain	Residue	Details
A	CYS13
A	ARG19
A	CYS18
A	ASP132

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1pnt

Chain	Residue	Details
B	CYS13
B	ARG19
B	CYS18
B	ASP132

---