Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1D1J

CRYSTAL STRUCTURE OF HUMAN PROFILIN II

Functional Information from GO Data
ChainGOidnamespacecontents
A0003779molecular_functionactin binding
A0003785molecular_functionactin monomer binding
A0005515molecular_functionprotein binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005737cellular_componentcytoplasm
A0005856cellular_componentcytoskeleton
A0010633biological_processnegative regulation of epithelial cell migration
A0016887molecular_functionATP hydrolysis activity
A0030036biological_processactin cytoskeleton organization
A0030833biological_processregulation of actin filament polymerization
A0030837biological_processnegative regulation of actin filament polymerization
A0030838biological_processpositive regulation of actin filament polymerization
A0032233biological_processpositive regulation of actin filament bundle assembly
A0032781biological_processpositive regulation of ATP-dependent activity
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0044087biological_processregulation of cellular component biogenesis
A0050804biological_processmodulation of chemical synaptic transmission
A0050821biological_processprotein stabilization
A0051496biological_processpositive regulation of stress fiber assembly
A0070062cellular_componentextracellular exosome
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098885biological_processmodification of postsynaptic actin cytoskeleton
A0098978cellular_componentglutamatergic synapse
A0099171biological_processpresynaptic modulation of chemical synaptic transmission
A0110053biological_processregulation of actin filament organization
A1900028biological_processnegative regulation of ruffle assembly
A2000300biological_processregulation of synaptic vesicle exocytosis
B0003779molecular_functionactin binding
B0003785molecular_functionactin monomer binding
B0005515molecular_functionprotein binding
B0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
B0005737cellular_componentcytoplasm
B0005856cellular_componentcytoskeleton
B0010633biological_processnegative regulation of epithelial cell migration
B0016887molecular_functionATP hydrolysis activity
B0030036biological_processactin cytoskeleton organization
B0030833biological_processregulation of actin filament polymerization
B0030837biological_processnegative regulation of actin filament polymerization
B0030838biological_processpositive regulation of actin filament polymerization
B0032233biological_processpositive regulation of actin filament bundle assembly
B0032781biological_processpositive regulation of ATP-dependent activity
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0044087biological_processregulation of cellular component biogenesis
B0050804biological_processmodulation of chemical synaptic transmission
B0050821biological_processprotein stabilization
B0051496biological_processpositive regulation of stress fiber assembly
B0070062cellular_componentextracellular exosome
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098793cellular_componentpresynapse
B0098794cellular_componentpostsynapse
B0098885biological_processmodification of postsynaptic actin cytoskeleton
B0098978cellular_componentglutamatergic synapse
B0099171biological_processpresynaptic modulation of chemical synaptic transmission
B0110053biological_processregulation of actin filament organization
B1900028biological_processnegative regulation of ruffle assembly
B2000300biological_processregulation of synaptic vesicle exocytosis
C0003779molecular_functionactin binding
C0003785molecular_functionactin monomer binding
C0005515molecular_functionprotein binding
C0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
C0005737cellular_componentcytoplasm
C0005856cellular_componentcytoskeleton
C0010633biological_processnegative regulation of epithelial cell migration
C0016887molecular_functionATP hydrolysis activity
C0030036biological_processactin cytoskeleton organization
C0030833biological_processregulation of actin filament polymerization
C0030837biological_processnegative regulation of actin filament polymerization
C0030838biological_processpositive regulation of actin filament polymerization
C0032233biological_processpositive regulation of actin filament bundle assembly
C0032781biological_processpositive regulation of ATP-dependent activity
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0044087biological_processregulation of cellular component biogenesis
C0050804biological_processmodulation of chemical synaptic transmission
C0050821biological_processprotein stabilization
C0051496biological_processpositive regulation of stress fiber assembly
C0070062cellular_componentextracellular exosome
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098793cellular_componentpresynapse
C0098794cellular_componentpostsynapse
C0098885biological_processmodification of postsynaptic actin cytoskeleton
C0098978cellular_componentglutamatergic synapse
C0099171biological_processpresynaptic modulation of chemical synaptic transmission
C0110053biological_processregulation of actin filament organization
C1900028biological_processnegative regulation of ruffle assembly
C2000300biological_processregulation of synaptic vesicle exocytosis
D0003779molecular_functionactin binding
D0003785molecular_functionactin monomer binding
D0005515molecular_functionprotein binding
D0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
D0005737cellular_componentcytoplasm
D0005856cellular_componentcytoskeleton
D0010633biological_processnegative regulation of epithelial cell migration
D0016887molecular_functionATP hydrolysis activity
D0030036biological_processactin cytoskeleton organization
D0030833biological_processregulation of actin filament polymerization
D0030837biological_processnegative regulation of actin filament polymerization
D0030838biological_processpositive regulation of actin filament polymerization
D0032233biological_processpositive regulation of actin filament bundle assembly
D0032781biological_processpositive regulation of ATP-dependent activity
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0044087biological_processregulation of cellular component biogenesis
D0050804biological_processmodulation of chemical synaptic transmission
D0050821biological_processprotein stabilization
D0051496biological_processpositive regulation of stress fiber assembly
D0070062cellular_componentextracellular exosome
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098793cellular_componentpresynapse
D0098794cellular_componentpostsynapse
D0098885biological_processmodification of postsynaptic actin cytoskeleton
D0098978cellular_componentglutamatergic synapse
D0099171biological_processpresynaptic modulation of chemical synaptic transmission
D0110053biological_processregulation of actin filament organization
D1900028biological_processnegative regulation of ruffle assembly
D2000300biological_processregulation of synaptic vesicle exocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 800
ChainResidue
AARG88
AASN99
AHIS119
AGLY120
CARG74

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 801
ChainResidue
BHOH206
BHOH561
DARG74
BARG88
BASN99
BHIS119
BGLY120

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 C 802
ChainResidue
AHOH414
CARG88
CASN99
CHIS119
CGLY120
CHOH425

site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 D 803
ChainResidue
BARG74
BHOH574
BHOH577
DASN99
DHIS119
DGLY120
DHOH575

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PG6 C 901
ChainResidue
CSER5
CASN9
CCYS12
CTYR133
DSER5
DASN9

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE PG5 D 902
ChainResidue
CASP26
CALA27
CTYR29
DASP26
DALA27
DTYR29
DTRP31

Functional Information from PROSITE/UniProt
site_idPS00414
Number of Residues8
DetailsPROFILIN Profilin signature. .AgWQsYvD
ChainResidueDetails
AALA1-ASP8

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:22223895
ChainResidueDetails
AALA1
BALA1
CALA1
DALA1

222624

PDB entries from 2024-07-17

PDB statisticsPDBj update infoContact PDBjnumon